The inflammasome is a platform for inflammatory signaling, and the NLRP3 inflammasome
recognizes stimuli in vitro and in vivo, and releases inflammatory cytokines that trigger …

The NOD‐like receptor family pyrin domain containing 6 (NLRP6), a member of the NOD‐
like receptor (NLR) family, acts as a cytosolic innate immune sensor that recognizes microbe …

Within the NOD‐like receptor (NLR) family, there are several NLRP (NLR family, pyrin
domain‐containing) proteins that are involved in the formation of inflammasomes. These …

Several lines of evidence point out the relevance of nucleotide-binding oligomerization
domain leucine rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome …

Background Attenuated innate immune responses to the intestinal microbiota have been
linked to the pathogenesis of Crohn's disease (CD). Recent genetic studies have revealed …

Inflammasomes are multiprotein intracellular complexes which are responsible for the
activation of inflammatory responses. Among various subtypes of inflammasomes, NLRP3 …

The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family, pyrin
domain-containing protein 3 (NLRP3) inflammasome, is one of the most well-characterized …

NLRP3 inflammasome can be widely found in epithelial cells and immune cells. The NOD-
like receptors (NLRs) family member NLRP3 contains a central nucleotide-binding and …

Inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis constitute
a major health problem in developed countries. Moreover, IBD predisposes to the …

Mucus production by goblet cells of the large intestine serves as a crucial antimicrobial
protective mechanism at the interface between the eukaryotic and prokaryotic cells of the …