Malaria parasite pre-erythrocytic stage infection: gliding and hiding

AM Vaughan, ASI Aly, SHI Kappe - Cell host & microbe, 2008 - cell.com
In malaria, the red blood cell-infectious form of the Plasmodium parasite causes illness and
the possible death of infected hosts. The initial infection in the liver caused by the mosquito …

Malaria parasite pre‐erythrocytic infection: preparation meets opportunity

SE Lindner, JL Miller, SHI Kappe - Cellular microbiology, 2012 - Wiley Online Library
For those stricken with malaria, the classic clinical symptoms are caused by the parasite's
cyclic infection of red blood cells. However, this erythrocytic phase of the parasite's life cycle …

Sneaking in through the back entrance: the biology of malaria liver stages

U Frevert - Trends in parasitology, 2004 - cell.com
Malaria infection is caused by sporozoites, the life cycle stage of Plasmodium that is
transmitted by female anopheline mosquitoes. The inoculated sporozoites migrate in the …

The elusive malaria sporozoite in the mammalian host

P Baldacci, R Ménard - Molecular microbiology, 2004 - Wiley Online Library
Malaria infection is initiated when Plasmodium sporozoites are injected into a host during
the bite of an infected mosquito. In the mammal, the sporozoite must rapidly reach an …

Live and let die: manipulation of host hepatocytes by exoerythrocytic Plasmodium parasites

A Sturm, V Heussler - Medical microbiology and immunology, 2007 - Springer
The generation of rodent Plasmodium strains expressing fluorescent proteins in all life cycle
stages has had a big impact on malaria research. With this tool in hand, for the first time it …

Extrahepatic exoerythrocytic forms of rodent malaria parasites at the site of inoculation: clearance after immunization, susceptibility to primaquine, and contribution to …

T Voza, JL Miller, SHI Kappe, P Sinnis - Infection and immunity, 2012 - Am Soc Microbiol
Plasmodium sporozoites are inoculated into the skin of the mammalian host as infected
mosquitoes probe for blood. A proportion of the inoculum enters the bloodstream and goes …

Malaria parasite liver infection and exoerythrocytic biology

AM Vaughan, SHI Kappe - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
In their infection cycle, malaria parasites undergo replication and population expansions
within the vertebrate host and the mosquito vector. Host infection initiates with sporozoite …

Host cell traversal is important for progression of the malaria parasite through the dermis to the liver

R Amino, D Giovannini, S Thiberge, P Gueirard… - Cell host & …, 2008 - cell.com
The malaria sporozoite, the parasite stage transmitted by the mosquito, is delivered into the
dermis and differentiates in the liver. Motile sporozoites can invade host cells by disrupting …

Malaria parasite development in the mosquito and infection of the mammalian host

ASI Aly, AM Vaughan, SHI Kappe - Annual review of …, 2009 - annualreviews.org
Plasmodium sporozoites are the product of a complex developmental process in the
mosquito vector and are destined to infect the mammalian liver. Attention has been drawn to …

Looking under the skin: the first steps in malarial infection and immunity

R Ménard, J Tavares, I Cockburn, M Markus… - Nature Reviews …, 2013 - nature.com
Malaria, which is caused by Plasmodium spp., starts with an asymptomatic phase, during
which sporozoites, the parasite form that is injected into the skin by a mosquito, develop into …