Metazoan parasite vaccines: present status and future prospects

C Stutzer, SA Richards, M Ferreira, S Baron… - Frontiers in cellular …, 2018 - frontiersin.org
Eukaryotic parasites and pathogens continue to cause some of the most detrimental and
difficult to treat diseases (or disease states) in both humans and animals, while also …

Promising technologies in the field of helminth vaccines

DJ Perera, M Ndao - Frontiers in immunology, 2021 - frontiersin.org
Helminths contribute a larger global burden of disease than both malaria and tuberculosis.
These eukaryotes have caused human infections since before our earliest recorded history …

Identifying novel candidates and configurations for human helminth vaccines

RM Maizels - Expert Review of Vaccines, 2021 - Taylor & Francis
Introduction: Human infections with helminth worm parasites are extraordinarily prevalent
across tropical and subtropical parts of the world, and control relies primarily on drugs that …

Exploiting natural immunity to helminth parasites for the development of veterinary vaccines

ENT Meeusen, D Piedrafita - International journal for parasitology, 2003 - Elsevier
The development of subunit vaccines against most parasitic helminth infections will require
a better understanding of the different components of a natural rejection process including …

Vaccination against helminth parasite infections

JP Hewitson, RM Maizels - Expert review of vaccines, 2014 - Taylor & Francis
Helminth parasites infect over one fourth of the human population and are highly prevalent
in livestock worldwide. In model systems, parasites are strongly immunomodulatory, but the …

Vaccination against helminth parasites‐the ultimate challenge for vaccinologists?

RM Maizels, MJ Holland, FH Falcone… - Immunological …, 1999 - Wiley Online Library
Helminths are multicellular pathogens which infect vast numbers of human and animal
hosts, causing widspread chronic disease and morbidity, Vaccination against these …

How to train your myeloid cells: a way forward for helminth vaccines?

R Doolan, N Putananickal, L Tritten… - Frontiers in …, 2023 - frontiersin.org
Soil-transmitted helminths affect approximately 1.5 billion people worldwide. However, as no
vaccine is currently available for humans, the current strategy for elimination as a public …

Veterinary parasitic vaccines: pitfalls and future directions

J Vercruysse, DP Knox, TPM Schetters… - Trends in …, 2004 - cell.com
Most available antiparasitic drugs are safe, cheap and highly effective against a broad
spectrum of parasites. However, the alarming increase in the number of parasite species …

Lessons along the critical path: developing vaccines against human helminths

DJ Diemert, ME Bottazzi, J Plieskatt, PJ Hotez… - Trends in …, 2018 - cell.com
Helminthic parasites are important targets for vaccine research as they infect an estimated 1
billion people worldwide. Despite significant progress in the discovery of defined antigens …

The immune response to parasitic helminths of veterinary importance and its potential manipulation for future vaccine control strategies

N Foster, HM Elsheikha - Parasitology research, 2012 - Springer
Despite the increasing knowledge of the immunobiology and epidemiology of parasitic
helminths of the gastrointestinal system and the cardiorespiratory system, complications …