TGFβ drives metabolic perturbations during epithelial mesenchymal transition in pancreatic cancer: TGFβ induced EMT in PDAC
Simple Summary Pancreatic cancer is an aggressive disease with most patients diagnosed
at late stages resulting in poor outcomes. While it is known that pancreatic tumor cells …
at late stages resulting in poor outcomes. While it is known that pancreatic tumor cells …
Metabolomic profiling of pancreatic adenocarcinoma reveals key features driving clinical outcome and drug resistance
A El Kaoutari, NA Fraunhoffer, O Hoare… - …, 2021 - thelancet.com
Background Although significant advances have been made recently to characterize the
biology of pancreatic ductal adenocarcinoma (PDAC), more efforts are needed to improve …
biology of pancreatic ductal adenocarcinoma (PDAC), more efforts are needed to improve …
Metabolic tumor burden: a new promising way to reach precise personalized therapy in PDAC
J Xiang, L Liu, W Wang, H Xu, C Wu, J Xu, C Liu… - Cancer letters, 2015 - Elsevier
Pancreatic cancer is currently one of the deadliest solid malignancies and pancreatic ductal
adenocarcinoma (PDAC) is the most common type of pancreatic cancer. In the past decade …
adenocarcinoma (PDAC) is the most common type of pancreatic cancer. In the past decade …
[HTML][HTML] Metabolism remodeling in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is predicted to become the second leading
cause of death of patients with malignant cancers by 2030. Current options of PDAC …
cause of death of patients with malignant cancers by 2030. Current options of PDAC …
Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets
HB Andersen, R Ialchina, SF Pedersen… - Cancer and Metastasis …, 2021 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers globally with a
mortality rate exceeding 95% and very limited therapeutic options. A hallmark of PDAC is its …
mortality rate exceeding 95% and very limited therapeutic options. A hallmark of PDAC is its …
Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer
G Zhang, P He, H Tan, A Budhu, J Gaedcke… - Clinical cancer …, 2013 - AACR
Purpose: To identify metabolic pathways that are perturbed in pancreatic ductal
adenocarcinoma (PDAC), we investigated gene-metabolite networks with integration of …
adenocarcinoma (PDAC), we investigated gene-metabolite networks with integration of …
TGFβ-induced metabolic reprogramming during epithelial-to-mesenchymal transition in cancer
Metastasis is the most frequent cause of death in cancer patients. Epithelial-to-mesenchymal
transition (EMT) is the process in which cells lose epithelial integrity and become motile, a …
transition (EMT) is the process in which cells lose epithelial integrity and become motile, a …
Orchestration of mesenchymal plasticity and immune evasiveness via rewiring of the metabolic program in pancreatic ductal adenocarcinoma
A Hashimoto, H Handa, S Hata, S Hashimoto - Frontiers in Oncology, 2022 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) is the most fatal cancer in humans, due to its
difficulty of early detection and its high metastatic ability. The occurrence of epithelial to …
difficulty of early detection and its high metastatic ability. The occurrence of epithelial to …
Epithelial-mesenchymal transition induction is associated with augmented glucose uptake and lactate production in pancreatic ductal adenocarcinoma
Background Pancreatic ductal adenocarcinoma (PDAC) is a common malignancy with
dismal prognosis. Metastatic spread and therapeutic resistance, the main causes of PDAC …
dismal prognosis. Metastatic spread and therapeutic resistance, the main causes of PDAC …
Metabolic rewiring and stemness: a critical attribute of pancreatic cancer progression
AO Ogunleye, RK Nimmakayala, SK Batra… - Stem Cells, 2023 - academic.oup.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive diseases with a
poor 5-year survival rate. PDAC cells rely on various metabolic pathways to fuel their …
poor 5-year survival rate. PDAC cells rely on various metabolic pathways to fuel their …