The blood–brain barrier (BBB) is a complex vascular structure consisting of microvascular
endothelial cells that line the vessel wall, astrocyte end‐feet, pericytes, as well as the basal …

Abstract Ogunshola, Omolara O and Abraham Al-Ahmad. HIF-1 at the blood-brain barrier: A
mediator of permeability? High Alt Med Biol 13: 153–161, 2012.—The importance of the …

The blood–brain barrier (BBB) constitutes a critical barrier for the maintenance of central
nervous system homeostasis. Brain microvascular endothelial cells line the vessel walls and …

Hypoxia is linked to changes in blood-brain barrier (BBB) permeability, and loss of BBB
integrity is characteristic of many pathological brain diseases including stroke. In particular …

Hypoxia is one of the most common pathological conditions, which can be induced by
multiple events, including ischemic injury, trauma, inflammation, tumors, etc. The body's …

Hypoxia, due to impaired cerebral blood flow, has hazardous effects on brain structure and
function. Therefore, mechanisms should exist to meet the needs for hypoxic adaptation via …

Hypoxia-inducible factor 1 (HIF-1) is a master regulator of cellular adaptation to hypoxia and
has been suggested as a potent therapeutic target in cerebral ischemia. Here we show in an …

The brain, as a very high energy consumer, is completely reliant on molecular oxygen but
because oxygen is dangerous due to toxicity, there are mechanisms which allow the brain to …

This investigation focuses on transcription factor involvement in blood–brain barrier (BBB)
endothelial cell‐induced alterations under conditions of hypoxia and post …

Structural and functional integrity of brain function profoundly depends on a regular oxygen
and glucose supply. Any disturbance of this supply becomes life threatening and may result …