[PDF][PDF] FYN, SARS-CoV-2, and IFITM3 in the neurobiology of Alzheimer's
Abstract Introduction:(IFITM3) is an innate immune protein that has been identified as a
novel γ-secretase (γs) modulator. FYN is a kinase that stabilizes IFITM3 on the membrane …
novel γ-secretase (γs) modulator. FYN is a kinase that stabilizes IFITM3 on the membrane …
[HTML][HTML] FYN, SARS-CoV-2, and IFITM3 in the neurobiology of Alzheimer's disease
Introduction (IFITM3) is an innate immune protein that has been identified as a novel γ-
secretase (γs) modulator. FYN is a kinase that stabilizes IFITM3 on the membrane, primes …
secretase (γs) modulator. FYN is a kinase that stabilizes IFITM3 on the membrane, primes …
FYN, SARS-CoV-2, and IFITM3 in the Neurobiology of Alzheimer's Disease: A Regulatory Feedback Loop Governing Tau and Aβ Pathology
Introduction: IFITM3, an innate immune protein linked to COVID-19 severity, has recently
been identified as a novel γ-secretase modulator. Independent research has shown that …
been identified as a novel γ-secretase modulator. Independent research has shown that …
[HTML][HTML] Outside-in induction of the IFITM3 trafficking system by infections, including SARS-CoV-2, in the pathobiology of Alzheimer's disease
Background IFITM3 is a viral restriction protein that enables sequestration of viral particles
and subsequent trafficking to lysosomes. Recently, IFITM3 upregulation was found to induce …
and subsequent trafficking to lysosomes. Recently, IFITM3 upregulation was found to induce …
Abstract WP247: Two Novel Interferon Signaling Proteins (Ifi27l2a And Ifitm3) Regulate Microglial Inflammation With Brain Aging And Following Stroke.
GS Kim, T WU, A Andersohn, E Harmon, A Doan… - Stroke, 2022 - Am Heart Assoc
Interferon signaling drives neuroinflammation in AD and stroke. Microglia (MG) play a critical
role in initiating and spreading inflammation and are involved in the chronic recovery phase …
role in initiating and spreading inflammation and are involved in the chronic recovery phase …
Investigating the Potential Shared Molecular Mechanisms between COVID-19 and Alzheimer's Disease via Transcriptomic Analysis
Y Fan, X Liu, F Guan, X Hang, X He, J Jin - Viruses, 2024 - mdpi.com
SARS-CoV-2 caused the COVID-19 pandemic. COVID-19 may elevate the risk of cognitive
impairment and even cause dementia in infected individuals; it may accelerate cognitive …
impairment and even cause dementia in infected individuals; it may accelerate cognitive …
SARS-CoV-2 infection increases the gene expression profile for Alzheimer's disease risk
R Green, K Mayilsamy, AR McGill, TE Martinez… - … Therapy-Methods & …, 2022 - cell.com
The coronavirus disease 2019 (COVID-19) pandemic has caused over 600,000,000
infections globally thus far. Up to 30% of individuals with mild to severe disease develop …
infections globally thus far. Up to 30% of individuals with mild to severe disease develop …
Type I interferon signaling, cognition and neurodegeneration following COVID-19: update on a mechanistic pathogenetic model with implications for Alzheimer's …
GD Vavougios, VS Tseriotis, A Liampas… - Frontiers in Human …, 2024 - frontiersin.org
COVID-19's effects on the human brain reveal a multifactorial impact on cognition and the
potential to inflict lasting neuronal damage. Type I interferon signaling, a pathway that …
potential to inflict lasting neuronal damage. Type I interferon signaling, a pathway that …
A bridge between the innate immunity system and amyloid-β production in Alzheimer's disease
X Wang - Neuroscience Bulletin, 2021 - Springer
Extracellular deposition of amyloid-b (Ab) is one of the pathological hallmarks of Alzheimer's
disease (AD)[1]. It has emerged that innate immune activation plays an important role in AD …
disease (AD)[1]. It has emerged that innate immune activation plays an important role in AD …
Activity of Alzheimer's γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity
AY Yao, R Yan - Molecular Neurodegeneration, 2020 - Springer
The activity of γ-secretase is critical to the pathogenesis of Alzheimer's disease (AD). How its
activity is regulated is intriguing and highly important for any AD therapy that focuses on …
activity is regulated is intriguing and highly important for any AD therapy that focuses on …