T Liu, Y Tao, X Xia, Y Zhang, R Deng… - TrAC Trends in Analytical …, 2022 - Elsevier
Over the last decade, the biopharmaceutical market has witnessed a new wave of development in antibody–drug conjugates (ADCs) due to their high efficacy in cancer …
Y Matsuda, V Robles, MC Malinao, J Song… - Analytical …, 2019 - ACS Publications
Antibody–drug conjugates (ADCs) have become a major class of oncology biopharmaceuticals. Traditional ADCs have a stochastic distribution of cytotoxic drugs …
Z Tawfiq, Y Matsuda, MJ Alfonso, C Clancy… - Analytical …, 2020 - jstage.jst.go.jp
The production of antibody-drug conjugates (ADCs) has been in great demand in the field of cancer therapeutics. Although cysteine-based conjugation is the most common and well …
A Wagh, H Song, M Zeng, L Tao, TK Das - MAbs, 2018 - Taylor & Francis
Antibody-drug conjugates (ADCs) are a growing class of biotherapeutics in which a potent small molecule is linked to an antibody. ADCs are highly complex and structurally …
S Kaur, K Xu, OM Saad, RC Dere… - Bioanalysis, 2013 - Taylor & Francis
Antibody–drug conjugates (ADCs) are monoclonal antibodies with covalently bound cytotoxic drugs. They are designed to target tumor antigens selectively and offer the hope of …
K Xu, L Liu, R Dere, E Mai, R Erickson, A Hendricks… - Bioanalysis, 2013 - Taylor & Francis
Background: Antibody–drug conjugates (ADCs) are a new class of cancer therapeutics that deliver potent cytotoxins specifically to tumors to minimize systemic toxicity. However …
Antibody-drug conjugates (ADCs) are a unique class of biotherapeutics of inherent heterogeneity and correspondingly complex absorption, distribution, metabolism, and …
M Sauerborn, W van Dongen - BioDrugs, 2014 - Springer
Currently, the most bioanalytically challenging drugs are antibody–drug conjugates (ADCs), constructs comprising a monoclonal antibody and a cytotoxic drug connected by a linker …
SC Alley, KE Anderson - Current opinion in chemical biology, 2013 - Elsevier
Antibody–drug conjugates (ADCs) require multiple assays for analytical and bioanalytical characterization due to their heterogeneous and dynamic nature. These assays can help …