Recent advances in drug–antibody ratio determination of antibody–drug conjugates

Y Matsuda, BA Mendelsohn - Chemical and Pharmaceutical Bulletin, 2021 - jstage.jst.go.jp
Antibody–drug conjugates (ADCs) are biopharmaceuticals produced by chemically linking
small molecules (payloads) to antibodies that possess specific affinity for the target cell. The …

Analytical tools for antibody–drug conjugates: from in vitro to in vivo

T Liu, Y Tao, X Xia, Y Zhang, R Deng… - TrAC Trends in Analytical …, 2022 - Elsevier
Over the last decade, the biopharmaceutical market has witnessed a new wave of
development in antibody–drug conjugates (ADCs) due to their high efficacy in cancer …

Comparison of analytical methods for antibody–drug conjugates produced by chemical site-specific conjugation: first-generation AJICAP

Y Matsuda, V Robles, MC Malinao, J Song… - Analytical …, 2019 - ACS Publications
Antibody–drug conjugates (ADCs) have become a major class of oncology
biopharmaceuticals. Traditional ADCs have a stochastic distribution of cytotoxic drugs …

Analytical comparison of antibody-drug conjugates based on good manufacturing practice strategies

Z Tawfiq, Y Matsuda, MJ Alfonso, C Clancy… - Analytical …, 2020 - jstage.jst.go.jp
The production of antibody-drug conjugates (ADCs) has been in great demand in the field of
cancer therapeutics. Although cysteine-based conjugation is the most common and well …

Challenges and new frontiers in analytical characterization of antibody-drug conjugates

A Wagh, H Song, M Zeng, L Tao, TK Das - MAbs, 2018 - Taylor & Francis
Antibody-drug conjugates (ADCs) are a growing class of biotherapeutics in which a potent
small molecule is linked to an antibody. ADCs are highly complex and structurally …

Bioanalytical assay strategies for the development of antibody–drug conjugate biotherapeutics

S Kaur, K Xu, OM Saad, RC Dere… - Bioanalysis, 2013 - Taylor & Francis
Antibody–drug conjugates (ADCs) are monoclonal antibodies with covalently bound
cytotoxic drugs. They are designed to target tumor antigens selectively and offer the hope of …

Characterization of the drug-to-antibody ratio distribution for antibody–drug conjugates in plasma/serum

K Xu, L Liu, R Dere, E Mai, R Erickson, A Hendricks… - Bioanalysis, 2013 - Taylor & Francis
Background: Antibody–drug conjugates (ADCs) are a new class of cancer therapeutics that
deliver potent cytotoxins specifically to tumors to minimize systemic toxicity. However …

ADME considerations and bioanalytical strategies for pharmacokinetic assessments of antibody-drug conjugates

S Mou, Y Huang, AI Rosenbaum - Antibodies, 2018 - mdpi.com
Antibody-drug conjugates (ADCs) are a unique class of biotherapeutics of inherent
heterogeneity and correspondingly complex absorption, distribution, metabolism, and …

Practical considerations for the pharmacokinetic and immunogenic assessment of antibody–drug conjugates

M Sauerborn, W van Dongen - BioDrugs, 2014 - Springer
Currently, the most bioanalytically challenging drugs are antibody–drug conjugates (ADCs),
constructs comprising a monoclonal antibody and a cytotoxic drug connected by a linker …

Analytical and bioanalytical technologies for characterizing antibody–drug conjugates

SC Alley, KE Anderson - Current opinion in chemical biology, 2013 - Elsevier
Antibody–drug conjugates (ADCs) require multiple assays for analytical and bioanalytical
characterization due to their heterogeneous and dynamic nature. These assays can help …