Tumour formation involves random mutagenic events and positive evolutionary selection
acting on a subset of such events, referred to as driver mutations. A decade of careful …

A fundamental goal in cancer research is to understand the mechanisms of cell
transformation. This is key to developing more efficient cancer detection methods and …

Distinguishing the driver mutations from somatic mutations in a tumor genome is one of the
major challenges of cancer research. This challenge is more acute and far from solved for …

Cancer develops as a result of somatic mutation and clonal selection, but quantitative
measures of selection in cancer evolution are lacking. We adapted methods from molecular …

Cancer is the dysregulated proliferation of cells caused by acquired mutations in key driver
genes. The most frequently mutated driver genes promote tumorigenesis in various …

Next-generation sequencing has allowed identification of millions of somatic mutations and
epigenetic changes in cancer cells. A key challenge in interpreting cancer genomes and …

Cancer genomes contain large numbers of somatic mutations but few of these mutations
drive tumor development. Current approaches either identify driver genes on the basis of …

With the ability to fully sequence tumor genomes/exomes, the quest for cancer driver genes
can now be undertaken in an unbiased manner. However, obtaining a complete catalog of …

Highlights•Currently mutations are classified into drivers and passengers.•We suggest an
additional 'latent driver'classification.•Latent driver mutations behave as passengers and do …

Cancers develop as a result of driver mutations, that lead to clonal outgrowth and the
evolution of disease,. The discovery and functional characterization of individual driver …