Abstract SARS-CoV-2 papain-like protease (PLpro) covers multiple functions. Beside the
cysteine-protease activity, facilitating cleavage of the viral polypeptide chain, PLpro has the …

The COVID-19 pandemic has been disastrous to society and effective drugs are urgently
needed. The papain-like protease domain (PLpro) of SARS-CoV-2 (SCoV2) is …

Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), the pathogen of the
Coronavirus disease-19 (COVID-19), is still devastating the world causing significant chaos …

Emerging variants of SARS‐CoV‐2 and potential novel epidemic coronaviruses underline
the importance of investigating various viral proteins as potential drug targets. The papain …

The recent emergence of different SARS-CoV-2 variants creates an urgent need to develop
more effective therapeutic agents to prevent COVID-19 outbreaks. Among SARS-CoV-2 …

The COVID-19 pandemic has emerged as the biggest life-threatening disease of this
century. Whilst vaccination should provide a long-term solution, this is pitted against the …

The papain-like protease (PLpro) of SARS-CoV-2 is a validated antiviral drug target.
Through a fluorescence resonance energy transfer-based high-throughput screening and …

SARS-CoV-2 encodes two viral cysteine proteases, the main protease (Mpro) and the
papain-like protease (PLpro), both of which are validated antiviral drug targets. PLpro is …

As the pathogen of COVID‐19, SARS‐CoV‐2 encodes two essential cysteine proteases that
process the pathogen's two large polypeptide products pp1a and pp1ab in the human cell …

The coronavirus papain‐like protease (PLpro) plays an important role in the proteolytic
processing of viral polyproteins and the dysregulation of the host immune response …