This chapter reviews the state of knowledge with respect to skeletal mechanobiology. Forms
of tissue-level mechanical stimulation are first described, including electromagnetic fields …

Bone is one of the most adaptable tissues in the body as it is continuously subjected to load
bearing. In fact, mechanical loading is an important regulator of bone mass. The skeleton …

Skeletal loading is an important physiological regulator of bone mass. Theoretically,
mechanical forces or administration of drugs that activate bone mechanosensors would be a …

The skeleton has the ability to perfectly adapt to external forces of the operating
environment, by altering its morphology and metabolism in order to meet different needs …

Mechanotransduction in bone is fundamental to proper skeletal development. Deficiencies
in signaling mechanisms that transduce physical forces to effector cells can have severe …

Bone remodeling is the continuous turnover of bone matrix and mineral by bone resorption
(activity of osteoclasts) and formation (activity of osteoblasts) in the adult skeleton. The …

The skeleton is subject to dynamic changes throughout life and bone remodeling is
essential for maintenance of bone functionality. The cell populations which predominantly …

Bone demonstrates a remarkable ability to renew itself, adapt its architecture, and repair
fractures to maintain strength throughout life. Mechanobiology, the study of how external …

Bone tissue has the capacity to adapt to its functional environment such that its morphology
is “optimized” for the mechanical demand. The adaptive nature of the skeleton poses an …

Bone is a dynamic tissue that adjusts its structure over time to adapt to changes in
mechanical load. This adaptive ability is critical to skeletal development and maintenance of …