Enhancing protective immunity to malaria with a highly immunogenic virus-like particle vaccine
KA Collins, R Snaith, MG Cottingham, SC Gilbert… - Scientific reports, 2017 - nature.com
The leading malaria vaccine in development is the circumsporozoite protein (CSP)-based
particle vaccine, RTS, S, which targets the pre-erythrocytic stage of Plasmodium falciparum …
particle vaccine, RTS, S, which targets the pre-erythrocytic stage of Plasmodium falciparum …
Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection
L Foquet, CC Hermsen, GJ van Gemert… - The Journal of …, 2014 - Am Soc Clin Investig
Malaria, which is the result of Plasmodium falciparum infection, is a global health threat that
resulted in 655,000 deaths and 216 million clinical cases in 2010 alone. Recent phase 3 …
resulted in 655,000 deaths and 216 million clinical cases in 2010 alone. Recent phase 3 …
IgG2 Antibodies against a Clinical Grade Plasmodium falciparum CSP Vaccine Antigen Associate with Protection against Transgenic Sporozoite Challenge in Mice
R Schwenk, M DeBot, M Porter, J Nikki, L Rein… - PloS one, 2014 - journals.plos.org
The availability of a highly purified and well characterized circumsporozoite protein (CSP) is
essential to improve upon the partial success of recombinant CSP-based malaria vaccine …
essential to improve upon the partial success of recombinant CSP-based malaria vaccine …
Malaria vaccines: are we getting closer?
JE Epstein, B Giersing, G Mullen… - Current opinion in …, 2007 - europepmc.org
Forty years ago, researchers first demonstrated that immunization with irradiated sporozoites
could protect against malaria infection, providing the impetus for the development of a …
could protect against malaria infection, providing the impetus for the development of a …
Protective Antibody and CD8+ T-Cell Responses to the Plasmodium falciparum Circumsporozoite Protein Induced by a Nanoparticle Vaccine
SA Kaba, ME McCoy, TAPF Doll, C Brando, Q Guo… - PLoS …, 2012 - journals.plos.org
Background The worldwide burden of malaria remains a major public health problem due, in
part, to the lack of an effective vaccine against the Plasmodium falciparum parasite. An …
part, to the lack of an effective vaccine against the Plasmodium falciparum parasite. An …
Multifunctional antibodies are induced by the RTS, S malaria vaccine and associated with protection in a phase 1/2a trial
L Kurtovic, T Atre, G Feng, BD Wines… - The Journal of …, 2021 - academic.oup.com
Background RTS, S is the leading malaria vaccine candidate but only confers partial efficacy
against malaria in children. RTS, S is based on the major Plasmodium falciparum sporozoite …
against malaria in children. RTS, S is based on the major Plasmodium falciparum sporozoite …
Model for In Vivo Assessment of Humoral Protection against Malaria Sporozoite Challenge by Passive Transfer of Monoclonal Antibodies and Immune Serum
BK Sack, JL Miller, AM Vaughan, A Douglass… - Infection and …, 2014 - Am Soc Microbiol
Evidence from clinical trials of malaria vaccine candidates suggests that both cell-mediated
and humoral immunity to pre-erythrocytic parasite stages can provide protection against …
and humoral immunity to pre-erythrocytic parasite stages can provide protection against …
Improved T cell responses to Plasmodium falciparum circumsporozoite protein in mice and monkeys induced by a novel formulation of RTS, S vaccine antigen
P Mettens, PM Dubois, MA Demoitié, B Bayat… - Vaccine, 2008 - Elsevier
Protection against Plasmodium falciparum sporozoite infection can be achieved by
vaccination with the recombinant circumsporozoite protein-based vaccine RTS, S formulated …
vaccination with the recombinant circumsporozoite protein-based vaccine RTS, S formulated …
A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum
N Beutler, T Pholcharee, D Oyen… - PLoS …, 2022 - journals.plos.org
Potent and durable vaccine responses will be required for control of malaria caused by
Plasmodium falciparum (Pf). RTS, S/AS01 is the first, and to date, the only vaccine that has …
Plasmodium falciparum (Pf). RTS, S/AS01 is the first, and to date, the only vaccine that has …
The Relationship between RTS,S Vaccine-Induced Antibodies, CD4+ T Cell Responses and Protection against Plasmodium falciparum Infection
MT White, P Bejon, A Olotu, JT Griffin, EM Riley… - PloS one, 2013 - journals.plos.org
Vaccination with the pre-erythrocytic malaria vaccine RTS, S induces high levels of
antibodies and CD4+ T cells specific for the circumsporozoite protein (CSP). Using a …
antibodies and CD4+ T cells specific for the circumsporozoite protein (CSP). Using a …