The world raced to develop vaccines to protect against the rapid spread of SARS-CoV-2
infection upon the recognition of COVID-19 as a global pandemic. A broad spectrum of …

The success of mRNA vaccines during the COVID-19 pandemic has greatly accelerated the
development of mRNA therapy. mRNA is a negatively charged nucleic acid that serves as a …

Conspectus Since the US Food and Drug Administration (FDA) granted emergency use
authorization for two mRNA vaccines against SARS-CoV-2, mRNA-based technology has …

The recent success of mRNA vaccines in SARS-CoV-2 clinical trials is in part due to the
development of lipid nanoparticle delivery systems that not only efficiently express the …

Nucleic acid therapeutics offer a new paradigm to rapidly respond to global health problems.
The versatility of nucleic acids, especially in RNA therapies, provides the ability to tune …

Lipid nanoparticles (LNPs) have recently emerged as one of the most advanced
technologies for the highly efficient in vivo delivery of exogenous mRNA, particularly for …

Lipid nanoparticles (LNPs) are an emerging vehicle for gene delivery that accommodate
both nucleic acid and protein. Based on the experience of therapeutic liposomes, current …

Conspectus mRNA drugs can preempt infectious disease and treat Mendelian disorders,
such as sickle cell anemia, muscular dystrophy, and cystic fibrosis, as well as autoimmunity …

Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …

Abstract mRNA-based drugs have tremendous potential as clinical treatments, however, a
major challenge in realizing this drug class will promise to develop methods for safely …