Design and structure of an engineered disulfide-stabilized influenza virus hemagglutinin trimer
We engineered a disulfide-stabilized influenza virus hemagglutinin (HA) trimer, termed HA3-
SS, by introducing cysteine residues into the HA stem to covalently bridge the three …
SS, by introducing cysteine residues into the HA stem to covalently bridge the three …
Influenza chimeric hemagglutinin structures in complex with broadly protective antibodies to the stem and trimer interface
Influenza virus hemagglutinin (HA) has been the primary target for influenza vaccine
development. Broadly protective antibodies targeting conserved regions of the HA unlock …
development. Broadly protective antibodies targeting conserved regions of the HA unlock …
Conformational modulation of influenza virus hemagglutinin: characterization and in vivo efficacy of monomeric form
JH Seok, J Kim, DB Lee, KJ Cho, JH Lee, G Bae… - Scientific Reports, 2017 - nature.com
Mutational changes that mostly occur at the head region of hemagglutinin (HA) lead to the
emergence of new epidemic influenza viruses, whereas HA antigens have been modified to …
emergence of new epidemic influenza viruses, whereas HA antigens have been modified to …
Production and stabilization of the trimeric influenza hemagglutinin stem domain for potentially broadly protective influenza vaccines
The rapid dissemination of the 2009 pandemic H1N1 influenza virus emphasizes the need
for universal influenza vaccines that would broadly protect against multiple mutated strains …
for universal influenza vaccines that would broadly protect against multiple mutated strains …
Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions
FJ Milder, M Jongeneelen, T Ritschel… - Proceedings of the …, 2022 - National Acad Sciences
For an efficacious vaccine immunogen, influenza hemagglutinin (HA) needs to maintain a
stable quaternary structure, which is contrary to the inherently dynamic and metastable …
stable quaternary structure, which is contrary to the inherently dynamic and metastable …
Influenza hemagglutinin structures and antibody recognition
NC Wu, IA Wilson - Cold Spring Harbor …, 2020 - perspectivesinmedicine.cshlp.org
Hemagglutinin (HA) is most abundant glycoprotein on the influenza virus surface. Influenza
HA promotes viral entry by engaging the receptor and mediating virus–host membrane …
HA promotes viral entry by engaging the receptor and mediating virus–host membrane …
Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains
Seasonal influenza virus infections can cause significant morbidity and mortality, but the
threat from the emergence of a new pandemic influenza strain might have potentially even …
threat from the emergence of a new pandemic influenza strain might have potentially even …
Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection
VVA Mallajosyula, M Citron, F Ferrara… - Proceedings of the …, 2014 - National Acad Sciences
Influenza hemagglutinin (HA) is the primary target of the humoral response during
infection/vaccination. Current influenza vaccines typically fail to elicit/boost broadly …
infection/vaccination. Current influenza vaccines typically fail to elicit/boost broadly …
Mutations in or near the fusion peptide of the influenza virus hemagglutinin affect an antigenic site in the globular region
JW Yewdell, A Taylor, A Yellen, A Caton… - Journal of …, 1993 - Am Soc Microbiol
We previously described a monoclonal antibody (Y8-10C2) that binds influenza virus
hemagglutinin (HA) monomers but not native trimers. In this study, we demonstrated that Y8 …
hemagglutinin (HA) monomers but not native trimers. In this study, we demonstrated that Y8 …
Cryo-electron microscopy structures of chimeric hemagglutinin displayed on a universal influenza vaccine candidate
Influenza viruses expressing chimeric hemagglutinins (HAs) are important tools in the quest
for a universal vaccine. Using cryo-electron tomography, we have determined the structures …
for a universal vaccine. Using cryo-electron tomography, we have determined the structures …