Identification of host genomic biomarkers from multiple transcriptomics datasets for diagnosis and therapies of SARS-CoV-2 infections

B Sarker, MM Rahaman, MA Islam, MH Alamin… - Plos one, 2023 - journals.plos.org
The pandemic of COVID-19 is a severe threat to human life and the global economy.
Despite the success of vaccination efforts in reducing the spread of the virus, the situation …

Computational identification of host genomic biomarkers highlighting their functions, pathways and regulators that influence SARS-CoV-2 infections and drug …

MP Mosharaf, MS Reza, MK Kibria, FF Ahmed… - Scientific reports, 2022 - nature.com
The pandemic threat of COVID-19 has severely destroyed human life as well as the
economy around the world. Although, the vaccination has reduced the outspread, but …

Bioinformatics and machine learning approach identifies potential drug targets and pathways in COVID-19

MR Auwul, MR Rahman, E Gov… - Briefings in …, 2021 - academic.oup.com
Abstract Current coronavirus disease-2019 (COVID-19) pandemic has caused massive loss
of lives. Clinical trials of vaccines and drugs are currently being conducted around the world; …

Identification of host transcriptome-guided repurposable drugs for SARS-CoV-1 infections and their validation with SARS-CoV-2 infections by using the integrated …

FF Ahmed, MS Reza, MS Sarker, MS Islam… - PLoS …, 2022 - journals.plos.org
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is one of the most severe
global pandemic due to its high pathogenicity and death rate starting from the end of 2019 …

Weighted gene co-expression network analysis combined with machine learning validation to identify key modules and hub genes associated with SARS-CoV-2 …

H Karami, A Derakhshani, M Ghasemigol… - Journal of clinical …, 2021 - mdpi.com
The coronavirus disease-2019 (COVID-19) pandemic has caused an enormous loss of lives.
Various clinical trials of vaccines and drugs are being conducted worldwide; nevertheless …

Inferring SARS-CoV-2 functional genomics from viral transcriptome with identification of potential antiviral drugs and therapeutic targets

X Pan, X Li, S Ning, H Zhi - Cell & Bioscience, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused
by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and has posed a …

Integrated Bioinformatics Exploration and Preliminary Clinical Verification for the Identification of Crucial Biomarkers in Severe Cases of COVID-19

Z Huang, Z Cheng, X Deng, Y Yang, N Sun… - Journal of …, 2024 - Taylor & Francis
Background Coronavirus disease 2019 (COVID-19) is a respiratory infectious illness caused
by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The objective of this …

In Silico Identification and Analysis of Potentially Bioactive Antiviral Phytochemicals against SARS‐CoV‐2: A Molecular Docking and Dynamics Simulation Approach

SK Halder, I Sultana, MN Shuvo, A Shil… - BioMed Research …, 2023 - Wiley Online Library
SARS‐CoV‐2, a deadly coronavirus sparked COVID‐19 pandemic around the globe. With
an increased mutation rate, this infectious agent is highly transmissible inducing an …

Gene expression profiling of corona virus microarray datasets to identify crucial targets in COVID-19 patients

P Ramesh, S Veerappapillai, R Karuppasamy - Gene reports, 2021 - Elsevier
The current outbreak of coronavirus disease (COVID-19) has been affecting millions of
people and has caused devastating mortality worldwide. Moreover, it is to be noted that …

Identification of potential biomarkers and inhibitors for SARS-CoV-2 infection

H Gu, G Yuan - MedRxiv, 2020 - medrxiv.org
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has overwhelmed many health systems globally. Here, we aim to identify …