Effect of Cardiovascular Injury on Catabolism of Adenosine and Adenosine 5-'Triphosphate in Systemic Blood in a Freely Moving Rat Model In Vivo

PK Yeung, SS Kolathuru, RU Agu - Drug Metabolism Letters, 2016 - ingentaconnect.com
Background: Previous studies have shown that catabolism of adenosine 5'-triphosphate
(ATP) in red blood cell (RBC) may be a key factor for cardiovascular protection and …

Anti-ischemia drugs have no effect on the in vivo metabolism of ATP by RBC in normotensive restrained rats

PKF Yeung, J Dauphinee, K Simonson… - The Open Drug …, 2011 - benthamopen.com
The objective is to determine the effect of anti-ishemia agents on metabolism of adenosine-
5'-triphosphate (ATP) in red blood cell (RBC) in a normotensive rat model. Male Sprague …

A pilot study to assess adenosine 5'-triphosphate metabolism in red blood cells as a drug target for potential cardiovascular protection

P KF Yeung, J Tinkel, D Seeto - … & Haematological Disorders …, 2015 - ingentaconnect.com
Objective: To study the effect of exercise preconditioning on adenosine 5'triphosphate (ATP)
metabolism in red blood cells and cardiovascular protection against injury induced by …

Hemodynamic Assessment and In vivo Catabolism of Adenosine 5'-triphosphate in Doxorubicin or Isoproterenol-induced Cardiovascular Toxicity

PK Yeung, S Mohammadizadeh… - Drug Metabolism …, 2021 - ingentaconnect.com
Objective: Previous studies have shown that catabolism of adenosine 5'-triphosphate (ATP)
in systemic blood is a potential surrogate biomarker for cardiovascular toxicity. We …

Adenosine 5′-triphosphate metabolism in red blood cells as a potential biomarker for post-exercise hypotension and a drug target for cardiovascular protection

PK Yeung, SS Kolathuru, S Mohammadizadeh… - Metabolites, 2018 - mdpi.com
The importance of adenosine and ATP in regulating many biological functions has long
been recognized, especially for their effects on the cardiovascular system, which may be …

Adenosine and adenosine 5'-triphosphate catabolism in systemic blood as a potential biomarker for doxorubicin cardiotoxicity in an experimental rat model in vivo

PK Yeung, C Purcell, F Akhoundi… - … Disorders-Drug Targets …, 2018 - ingentaconnect.com
Background: Previous studies have shown that metabolism of adenosine 5'-triphosphate
(ATP) in systemic blood is a potential surrogate biomarker for cardiovascular toxicity …

Exercise improves hemodynamic profiles and increases red blood cell concentrations of purine nucleotides in a rodent model

PKF Yeung, J Dauphinee… - Therapeutic …, 2010 - journals.sagepub.com
Objective: To study the effect of exercise on hemodynamic profiles and red blood cell (RBC)
concentrations of adenosine-5'-triphosphate (ATP). Methods: Male Sprague-Dawley (SD) …

Diltiazem Reduces Mortality and Breakdown of ATP in Red Blood Cell Induced by Isoproterenol in a Freely Moving Rat Model in Vivo

PKF Yeung, Z Xu, D Seeto - Metabolites, 2014 - mdpi.com
The benefit of calcium channel blockers for cardiovascular prevention against heart attack
and stroke has not been firmly supported. We investigated the possible cardiovascular …

Sites and mechanism of adenosine formation in the cardiovascular system

J Schrader, U Decking - Drug development research, 1998 - Wiley Online Library
This review summarizes recent developments on the mechanisms by which adenosine is
formed in the cardiovascular system. The concept is developed that AMP is both a precursor …

Identification of adenosine 5'-tetraphosphate in rabbit platelets and its metabolism in blood

JW Lee, SJ Jeon, ID Kong… - Korean Journal of …, 1995 - yonsei.elsevierpure.com
Abstract Adenosine 5'-tetraphosphate (ATPP) was identified and quantified in extracts of
rabbit platelets by elution of extracts containing authentic adenosine 5'-tetraphosphate and …