We are witnessing a revolution in our understanding of primary aldosteronism (PA). In the
past 2 decades, we have learned that PA is a highly prevalent syndrome that is largely …

Primary aldosteronism (PA) is the most common form of secondary hypertension. In many
cases, somatic mutations in ion channels and pumps within adrenal cells initiate the …

It is now widely recognized that primary aldosteronism (PA) is much more common than
previously thought, accounting for up to 5–10% of hypertensives, and that aldosterone …

Context New approaches are needed to address the evolution of the primary aldosteronism
syndrome and to increase its recognition. Herein, we review evidence indicating that primary …

Primary aldosteronism (PA) is a condition well worth detecting because it is a common
cause of hypertension and is associated with excessive morbidity for the degree of …

In the 60 years that have passed since the discovery of the mineralocorticoid hormone
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …

Primary aldosteronism is characterized by aldosterone secretion that is independent of renin
and angiotensin II and sodium status. The deleterious effects of primary aldosteronism are …

Primary aldosteronism used to be considered a rare cause of secondary hypertension.
However, accruing evidence indicates that primary aldosteronism is more common than …

A significant proportion of hypertension (potentially more than 5% in the general population)
is due to primary aldosteronism (PA) which carries a worse prognosis when compared with …

Primary aldosteronism (PA) is the most common cause of secondary hypertension and is
associated with increased morbidity and mortality when compared with blood pressure …