[HTML][HTML] Preterm birth and sustained inflammation: consequences for the neonate

A Humberg, I Fortmann, B Siller, MV Kopp… - Seminars in …, 2020 - Springer
Almost half of all preterm births are caused or triggered by an inflammatory process at the
feto-maternal interface resulting in preterm labor or rupture of membranes with or without …

[HTML][HTML] Preterm birth, intrauterine infection, and fetal inflammation

MW Kemp - Frontiers in immunology, 2014 - frontiersin.org
Preterm birth (PTB)(delivery before 37 weeks' gestation) is a leading cause of neonatal
death and disease in industrialized and developing countries alike. Infection (most notably …

Intrauterine inflammation and preterm delivery

N Vrachnis, N Vitoratos, Z Iliodromiti… - Annals of the New …, 2010 - Wiley Online Library
Spontaneous preterm delivery, prematurity, and low birth weight due to prematurity account
for a great part of neonatal morbidity and mortality. Specifically, chronic amniotic fluid …

The developing human preterm neonatal immune system: a case for more research in this area

AA Sharma, R Jen, A Butler, PM Lavoie - Clinical immunology, 2012 - Elsevier
Neonates, particularly those born prematurely, are among the most vulnerable age group for
morbidity and mortality due to infections. Immaturity of the innate immune system and a high …

[HTML][HTML] Human perinatal immunity in physiological conditions and during infection

GTJ van Well, LA Daalderop, T Wolfs… - Molecular and cellular …, 2017 - Springer
The intrauterine environment was long considered sterile. However, several infectious
threats are already present during fetal life. This review focuses on the postnatal …

Inflammation and preterm birth

M Cappelletti, S Della Bella, E Ferrazzi… - Journal of Leucocyte …, 2016 - academic.oup.com
Preterm birth is the leading cause of neonatal morbidity and mortality. Although the
underlying causes of pregnancy-associated complication are numerous, it is well …

[HTML][HTML] Attenuated innate immune defenses in very premature neonates during the neonatal period

EA Marchant, B Kan, AA Sharma, A van Zanten… - Pediatric …, 2015 - nature.com
Background: Antimicrobial responses have been shown to be profoundly attenuated in very
preterm neonates when examined on cord blood. However, we lack data on these …

[HTML][HTML] Preterm birth: Inflammation, fetal injury and treatment strategies

AK Boyle, SF Rinaldi, JE Norman, SJ Stock - Journal of reproductive …, 2017 - Elsevier
Preterm birth (PTB) is the leading cause of childhood mortality in children under 5 and
accounts for approximately 11% of births worldwide. Premature babies are at risk of a …

Inflammation in pregnancy: its roles in reproductive physiology, obstetrical complications, and fetal injury

R Romero, F Gotsch, B Pineles… - Nutrition reviews, 2007 - academic.oup.com
Fetal development and growth occur in a sterile amniotic cavity while first exposure to
microorganisms happens at birth. However, at least 25% of all preterm births, the leading …

Immune status in very preterm neonates

M Azizia, J Lloyd, M Allen, N Klein, D Peebles - Pediatrics, 2012 - publications.aap.org
OBJECTIVES: Preterm neonates are at increased risk of sepsis compared with those born at
term. We investigated immune status at birth and early neonatal life in very preterm …