A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis
D Zhang, Y Liu, Y Zhu, Q Zhang, H Guan, S Liu… - Nature cell …, 2022 - nature.com
Innate DNA sensing via the cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS–
STING) mechanism surveys microbial invasion and cellular damage and thus participates in …
STING) mechanism surveys microbial invasion and cellular damage and thus participates in …
IRF3 activates RB to authorize cGAS-STING–induced senescence and mitigate liver fibrosis
Q Wu, X Leng, Q Zhang, YZ Zhu, R Zhou, Y Liu… - Science …, 2024 - science.org
Cytosolic double-stranded DNA surveillance by cyclic GMP-AMP synthase (cGAS)–
Stimulator of Interferon Genes (STING) signaling triggers cellular senescence, autophagy …
Stimulator of Interferon Genes (STING) signaling triggers cellular senescence, autophagy …
Crosstalk between cGAS–STING signaling and cell death
AMV Murthy, N Robinson, S Kumar - Cell Death & Differentiation, 2020 - nature.com
Cytosolic nucleic acid sensors have a critical role in detecting endogenous nucleic acids to
initiate innate immune responses during microbial infections and/or cell death. Several …
initiate innate immune responses during microbial infections and/or cell death. Several …
Research advances in how the cGAS-STING pathway controls the cellular inflammatory response
D Wan, W Jiang, J Hao - Frontiers in immunology, 2020 - frontiersin.org
Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …
Cellular functions of cGAS-STING signaling
C Chen, P Xu - Trends in cell biology, 2023 - cell.com
Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) senses misplaced genomic,
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …
[HTML][HTML] cGAS-STING pathway in oncogenesis and cancer therapeutics
The host innate immunity offers the first line of defense against infection. However, recent
evidence shows that the host innate immunity is also critical in sensing the presence of …
evidence shows that the host innate immunity is also critical in sensing the presence of …
cGAS‐cGAMP‐STING: the three musketeers of cytosolic DNA sensing and signaling
Innate immunity is the first line of host defense against invading pathogens. The detection of
aberrant nucleic acids which represent some conserved PAMPs triggers robust type I IFN …
aberrant nucleic acids which represent some conserved PAMPs triggers robust type I IFN …
STING signaling and sterile inflammation
I Couillin, N Riteau - Frontiers in Immunology, 2021 - frontiersin.org
Innate immunity is regulated by a broad set of evolutionary conserved receptors to finely
probe the local environment and maintain host integrity. Besides pathogen recognition …
probe the local environment and maintain host integrity. Besides pathogen recognition …
Sumoylation promotes the stability of the DNA sensor cGAS and the adaptor STING to regulate the kinetics of response to DNA virus
During viral infection, sensing of cytosolic DNA by the cyclic GMP-AMP synthase (cGAS)
activates the adaptor protein STING and triggers an antiviral response. Little is known about …
activates the adaptor protein STING and triggers an antiviral response. Little is known about …
Molecular mechanisms and cellular functions of cGAS–STING signalling
KP Hopfner, V Hornung - Nature reviews Molecular cell biology, 2020 - nature.com
The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …