A Metal‐Free Mesoporous Carbon Dots/Silica Hybrid Type I Photosensitizer with Enzyme‐Activity for Synergistic Treatment of Hypoxic Tumor

B Tian, S Liu, C Yu, S Liu, S Dong… - Advanced Functional …, 2023 - Wiley Online Library
As a less O2‐dependent photodynamic therapy (PDT), type I PDT is an effective approach to
overcome the hypoxia‐induced low efficiency against solid tumors. However, the commonly …

A Dual‐Nanozyme‐Catalyzed Cascade Reactor for Enhanced Photodynamic Oncotherapy against Tumor Hypoxia

M Chen, J Song, J Zhu, G Hong, J An… - Advanced …, 2021 - Wiley Online Library
Tumor hypoxia is a typical characteristic of tumor microenvironment (TME), which seriously
compromises the therapeutic effect of photodynamic therapy (PDT). The development of …

A novel theranostic nanoplatform based on Pd@ Pt‐PEG‐Ce6 for enhanced photodynamic therapy by modulating tumor hypoxia microenvironment

J Wei, J Li, D Sun, Q Li, J Ma, X Chen… - Advanced Functional …, 2018 - Wiley Online Library
Photodynamic therapy (PDT), which utilizes reactive oxygen species to kill cancer cells, has
found wide applications in cancer treatment. However, the hypoxic nature of most solid …

Biomimetic smart mesoporous carbon nanozyme as a dual-GSH depletion agent and O2 generator for enhanced photodynamic therapy

J Lu, Y Mao, S Feng, X Li, Y Gao, Q Zhao, S Wang - Acta Biomaterialia, 2022 - Elsevier
Photodynamic therapy (PDT) has been thriving in the theranostics of cancer in recent years.
However, due to a series of problems such as high concentration of GSH and insufficient O 2 …

Oxygen‐evolving mesoporous organosilica coated prussian blue nanoplatform for highly efficient photodynamic therapy of tumors

ZL Yang, W Tian, Q Wang, Y Zhao, YL Zhang… - Advanced …, 2018 - Wiley Online Library
Oxygen (O2) plays a critical role during photodynamic therapy (PDT), however, hypoxia is
quite common in most solid tumors, which limits the PDT efficacy and promotes the tumor …

An O2 Self‐Sufficient Biomimetic Nanoplatform for Highly Specific and Efficient Photodynamic Therapy

H Cheng, JY Zhu, SY Li, JY Zeng, Q Lei… - Advanced Functional …, 2016 - Wiley Online Library
Conventional oxygen‐dependent photodynamic therapy (PDT) has faced severe challenges
because of the non‐specificity of most available photosensitizers (PSs) and the hypoxic …

A mesoporous nanoenzyme derived from metal–organic frameworks with endogenous oxygen generation to alleviate tumor hypoxia for significantly enhanced …

D Wang, H Wu, WQ Lim, SZF Phua, P Xu… - Advanced …, 2019 - Wiley Online Library
Tumor hypoxia compromises the therapeutic efficiency of photodynamic therapy (PDT) as
the local oxygen concentration plays an important role in the generation of cytotoxic singlet …

Biodegradable calcium phosphate nanotheranostics with tumor‐specific activatable cascade catalytic reactions‐augmented photodynamic therapy

LH Fu, Y Wan, C Li, C Qi, T He, C Yang… - Advanced Functional …, 2021 - Wiley Online Library
Photodynamic therapy (PDT) is exploited as a promising strategy for cancer treatment.
However, the hypoxic solid tumor and the lack of tumor‐specific photosensitizer …

Construction of PEGylated chlorin e6@ CuS-Pt theranostic nanoplatforms for nanozymes-enhanced photodynamic-photothermal therapy

Y Sheng, Q Ren, C Tao, M Wen, P Qu, N Yu… - Journal of Colloid and …, 2023 - Elsevier
Multifunctional nanoagents with photodynamic therapy (PDT) and photothermal therapy
(PTT) functions have shown great promise for cancer treatment, while the design and …

Biomimetic O2-Evolving metal-organic framework nanoplatform for highly efficient photodynamic therapy against hypoxic tumor

S Gao, P Zheng, Z Li, X Feng, W Yan, S Chen, W Guo… - Biomaterials, 2018 - Elsevier
Improving the supply of O 2 and the circulation lifetime of photosensitizers for photodynamic
therapy (PDT) in vivo would be a promising approach to eliminate hypoxic tumors. Herein …