The precise circuit of the substantia nigra pars reticulata (SNr) involved in temporal lobe
epilepsy (TLE) is still unclear. Here we found that optogenetic or chemogenetic activation of …

The substantia nigra pars reticulata (SNR) represents an endogenous seizure suppressing
system, which may be targeted to develop treatments for generalized or multifocal …

Inhibitory synaptic mechanisms oppose epileptic network activity in the brain. The
breakdown in this inhibitory restraint and propagation of seizure activity has been linked to …

Impaired inhibition is thought to be important in temporal lobe epilepsy (TLE), the most
common form of epilepsy in adult patients. We report that, in experimental TLE, spontaneous …

Parvalbumin (Pv)-positive inhibitory interneurons effectively control network excitability, and
their optogenetic activation has been reported to block epileptic seizures. An intense activity …

Secondary generalized seizure (sGS) is a major source of disability in temporal lobe
epilepsy (TLE) with unclear cellular/circuit mechanisms. Here we found that clinical TLE …

Key points On‐demand optogenetic inhibition of glutamatergic neurons in the fastigial
nucleus of the cerebellum does not alter hippocampal seizures in a mouse model of …

GABAergic interneurons are thought to play a critical role in eliciting interictal spikes (IICs)
and triggering ictal discharges in temporal lobe epilepsy, yet the contribution of different …

The precise links between the observed gain of neocortical inhibition and development of
seizures in autosomal dominant nocturnal frontal lobe epilepsy mice remain unknown …

Mesial temporal lobe epilepsy (MTLE) is the most common type of focal refractory epilepsy
and is characterized by recurring seizures that are often refractory to medication. Since …