Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against
infections and regulates the innate and acquired immune response. IL-18 is produced by …

Abstract Interleukin (IL)-18, structurally similar to IL-1-, is a member of IL-1 superfamily of
cytokines. This cytokine, which is expressed by many human lymphoid and nonlymphoid …

Interleukin-18 is a member of the interleukin-1 family of cytokines with pro-inflammatory and
tumor-suppressive properties. Its ability to potently enhance the production of interferon-γ …

Publisher Summary Interleukin-18 (IL-18) is a multifunctional cytokine, the roles of which
extend over both acquired and innate immunity, and its major role has been thought to be …

Although emerging data shed more light on the complex role of IL-18 in immune reactions,
they also pose more questions. Given the pleiotropic, complex, and at times paradoxic …

Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines. Similar to IL-1β, IL-18 is
synthesized as an inactive precursor requiring processing by caspase-1 into an active …

Abstract Interleukin-17 (IL-17) is a proinflammatory cytokine involved in chronic inflammation
occurring during the pathogenesis of allergy, malignancy, and autoimmune diseases such …

Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from
anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag …

Interleukin 18 (IL-18) is a pleiotropic cytokine involved in the regulation of innate and
acquired immune response. In the milieu of IL-12 or IL-15, IL-18 is a potent inducer of IFN …

Several new discoveries have revived interest in the pathogenic potential and possible
clinical roles of IL-18. IL-18 is an IL-1 family cytokine with potent ability to induce IFNγ …