Mechanosensitive ion channels: their physiological importance and potential key role in cancer

Á Otero-Sobrino, P Blanco-Carlón… - International Journal of …, 2023 - mdpi.com
Mechanosensitive ion channels comprise a broad group of proteins that sense mechanical
extracellular and intracellular changes, translating them into cation influx to adapt and …

Mechanosensitive ion channels push cancer progression

Z Pethő, K Najder, E Bulk, A Schwab - Cell Calcium, 2019 - Elsevier
In many cases, the mechanical properties of a tumor are different from those of the host
tissue. Mechanical cues regulate cancer development by affecting both tumor cells and their …

The interplay between physical cues and mechanosensitive ion channels in cancer metastasis

K Bera, A Kiepas, Y Zhang, SX Sun… - Frontiers in Cell and …, 2022 - frontiersin.org
Physical cues have emerged as critical influencers of cell function during physiological
processes, like development and organogenesis, and throughout pathological …

Channeling force in the brain: mechanosensitive ion channels choreograph mechanics and malignancies

A Momin, S Bahrampour, HK Min, X Chen… - Trends in …, 2021 - cell.com
Force is everywhere. Through cell-intrinsic activities and interactions with the
microenvironment, cells generate, transmit, and sense mechanical forces, such as …

Mechanosensitive ion channels and their role in cancer cells

J Karska, S Kowalski, J Saczko, MG Moisescu… - Membranes, 2023 - mdpi.com
Mechanical forces are an inherent element in the world around us. The effects of their action
can be observed both on the macro and molecular levels. They can also play a prominent …

Piezo1 forms mechanosensitive ion channels in the human MCF-7 breast cancer cell line

C Li, S Rezania, S Kammerer, A Sokolowski… - Scientific reports, 2015 - nature.com
Mechanical interaction between cells–specifically distortion of tensional homeostasis-
emerged as an important aspect of breast cancer genesis and progression. We investigated …

[HTML][HTML] Mechano-gated ion channels in sensory systems

P Delmas, B Coste - Cell, 2013 - cell.com
Living organisms sense their physical environment through cellular mechanotransduction,
which converts mechanical forces into electrical and biochemical signals. In turn, signal …

[HTML][HTML] Mechanosensitive ion channels in cell migration

BC Coutino, R Mayor - Cells & Development, 2021 - Elsevier
Cellular processes are initiated and regulated by different stimuli, including mechanical
forces. Cell membrane mechanosensors represent the first step towards the conversion of …

Mechanosensitive ion channels: an evolutionary and scientific tour de force in mechanobiology

B Martinac - Channels, 2012 - Taylor & Francis
Correspondence to: Boris Martinac; Email: b. martinac@ victorchang. edu. au Submitted:
08/17/12; Accepted: 08/17/12 http://dx. doi. org/10.4161. chan. 22047 stretch-induced …

Mechanosensitive piezo channels in cancer: focus on altered calcium signaling in cancer cells and in tumor progression

D De Felice, A Alaimo - Cancers, 2020 - mdpi.com
Mechanotransduction, the translation of mechanical stimuli into biological signals, is a
crucial mechanism involved in the function of fundamentally all cell types. In many solid …