Deciphering a GPCR-lncrna-miRNA nexus: Identification of an aberrant therapeutic target in ovarian cancer

JH Ha, R Radhakrishnan, R Nadhan… - Cancer Letters, 2024 - Elsevier
Ovarian cancer ranks as a leading cause of mortality among gynecological malignancies,
primarily due to the lack of early diagnostic tools, effective targeted therapy, and clear …

lncRNA UCA1 mediates resistance to cisplatin by regulating the miR-143/FOSL2-signaling pathway in ovarian cancer

Z Li, H Niu, Q Qin, S Yang, Q Wang, C Yu, Z Wei… - … Therapy-Nucleic Acids, 2019 - cell.com
The aim of this study was to explore the roles of the long noncoding RNA (lncRNA) urothelial
carcinoma-associated 1 (UCA1) on cisplatin resistance in ovarian cancer and the underlying …

UCA1 functions as a competing endogenous RNA to suppress epithelial ovarian cancer metastasis

Y Yang, Y Jiang, Y Wan, L Zhang, J Qiu, S Zhou… - Tumor Biology, 2016 - Springer
Abstract Urothelial cancer associated 1 (UCA1) is an example of functional long noncoding
RNAs involved in many biologic processes. However, little is known about the association …

The lncRNA 'UCA1'modulates the response to chemotherapy of ovarian cancer through direct binding to miR‐27a‐5p and control of UBE2N levels

A Wambecke, M Ahmad, PM Morice… - Molecular …, 2021 - Wiley Online Library
Ovarian cancer (OC) is the leading cause of death in patients with gynecologic cancers. Due
to late diagnosis and resistance to chemotherapy, the 5‐year survival rate in patients with …

[HTML][HTML] Long non-coding RNA UCA1 promotes retinoblastoma progression by modulating the miR-124/c-myc axis

L Wang, M Wu, X Zhou - American Journal of Translational …, 2022 - ncbi.nlm.nih.gov
The long non-coding RNA (lncRNA), urothelial carcinoma-associated 1 (UCA1), belongs to
cancer-related lncRNAs implicated in various carcinomas, including colorectal and gastric …

Deciphering the Long Non-Coding RNAs and MicroRNAs Coregulation Networks in Ovarian Cancer Development: An Overview

C López-Camarillo, E Ruíz-García, YM Salinas-Vera… - Cells, 2021 - mdpi.com
Non-coding RNAs are emergent elements from the genome, which do not encode for
proteins but have relevant cellular functions impacting almost all the physiological …

LncRNA TMPO‐AS1 promotes LCN2 transcriptional activity and exerts oncogenic functions in ovarian cancer

H Zhao, F Ding, G Zheng - The FASEB Journal, 2020 - Wiley Online Library
Ovarian cancer remains the sixth most frequently occurring cancer in women worldwide.
Long noncoding RNAs (lncRNAs) are capable of regulating gene expression, and thus …

lncRNA UCA1 functions as a ceRNA to promote prostate cancer progression via sponging miR143

Y Yu, F Gao, Q He, G Li, G Ding - Molecular Therapy-Nucleic Acids, 2020 - cell.com
UCA1 (urothelial carcinoma associated 1) is a long non-coding RNA (lncRNA) that was
found overexpressed in various human cancers including prostate cancer (PCa). However …

lncRNA UCA1 predicts a poor prognosis and regulates cell proliferation and migration by repressing p21 and SPRY1 expression in GC

X He, J Wang, J Chen, L Han, X Lu, D Miao… - … Therapy-Nucleic Acids, 2019 - cell.com
Dysregulated expression of long non-coding RNAs (lncRNAs) has been reported in many
types of cancers, indicating that it has important regulatory roles in human cancer biology …

UCA1 confers paclitaxel resistance to ovarian cancer through miR-129/ABCB1 axis

J Wang, C Ye, J Liu, Y Hu - Biochemical and biophysical research …, 2018 - Elsevier
Increasing evidence has demonstrated the involvement of dysregulated long non-coding
RNAs (lncRNAs) in chemoresistance acting as potential oncogenes or tumor suppressors in …