Fully bioresorbable hybrid opto-electronic neural implant system for simultaneous electrophysiological recording and optogenetic stimulation

M Cho, JK Han, J Suh, JJ Kim, JR Ryu, IS Min… - Nature …, 2024 - nature.com
Bioresorbable neural implants based on emerging classes of biodegradable materials offer
a promising solution to the challenges of secondary surgeries for removal of implanted …

Ultra‐low cost, facile fabrication of transparent neural electrode array for electrocorticography with photoelectric artifact‐free optogenetics

YU Cho, JY Lee, UJ Jeong, SH Park… - Advanced Functional …, 2022 - Wiley Online Library
Transparent implantable devices have received significant attention in neuroscience and
biomedical engineering by combining neural recording and optical modalities. Opaque …

Validation of transparent and flexible neural implants for simultaneous electrophysiology, functional imaging, and optogenetics

L Koschinski, B Lenyk, M Jung, I Lenzi… - Journal of Materials …, 2023 - pubs.rsc.org
The combination of electrophysiology and neuroimaging methods allows the simultaneous
measurement of electrical activity signals with calcium dynamics from single neurons to …

Flexible optoelectric neural interfaces

Z Ahmed, JW Reddy, MH Malekoshoaraie… - Current opinion in …, 2021 - Elsevier
Understanding the neural basis of brain function and dysfunction and designing effective
therapeutics require high resolution targeted stimulation and recording of neural activity …

Multifunctional optrode for opsin delivery, optical stimulation, and electrophysiological recordings in freely moving rats

K Sharma, Z Jaeckel, A Schneider, O Paul… - Journal of Neural …, 2021 - iopscience.iop.org
Objective. Optogenetics involves delivery of light-sensitive opsins to the target brain region,
as well as introduction of optical and electrical devices to manipulate and record neural …

Flexible and stretchable opto-electric neural interface for low-noise electrocorticogram recordings and neuromodulation in vivo

B Ji, C Ge, Z Guo, L Wang, M Wang, Z Xie, Y Xu… - Biosensors and …, 2020 - Elsevier
Optogenetic-based neuromodulation tools is evolving for the basic neuroscience research in
animals combining optical manipulation and electrophysiological recordings. However …

Development of optically controlled “living electrodes” with long-projecting axon tracts for a synaptic brain-machine interface

DO Adewole, LA Struzyna, JC Burrell, JP Harris… - Science …, 2021 - science.org
For implantable neural interfaces, functional/clinical outcomes are challenged by limitations
in specificity and stability of inorganic microelectrodes. A biological intermediary between …

Implantable optoelectronic probes for in vivo optogenetics

E Iseri, D Kuzum - Journal of Neural Engineering, 2017 - iopscience.iop.org
More than a decade has passed since optics and genetics came together and lead to the
emerging technologies of optogenetics. The advent of light-sensitive opsins made it possible …

A chronically implantable bidirectional neural interface for non-human primates

M Komatsu, E Sugano, H Tomita, N Fujii - Frontiers in Neuroscience, 2017 - frontiersin.org
Optogenetics has potential applications in the study of epilepsy and neuroprostheses, and
for studies on neural circuit dynamics. However, to achieve translation to clinical usage …

[HTML][HTML] Injectable 2D flexible hydrogel sheets for optoelectrical/biochemical dual stimulation of neurons

J Amagat, CA Müller, BN Jensen, X Xiong, Y Su… - Biomaterials …, 2023 - Elsevier
Major challenges in developing implanted neural stimulation devices are the invasiveness,
complexity, and cost of the implantation procedure. Here, we report an injectable …