Biofilm antimicrobial susceptibility testing: where are we and where could we be going?

T Coenye - Clinical microbiology reviews, 2023 - Am Soc Microbiol
Our knowledge about the fundamental aspects of biofilm biology, including the mechanisms
behind the reduced antimicrobial susceptibility of biofilms, has increased drastically over the …

Should standardized susceptibility testing for microbial biofilms be introduced in clinical practice?

T Coenye, D Goeres… - Clinical …, 2018 - clinicalmicrobiologyandinfection …
Biofilms are communities of microbial cells that are attached to each other and/or a surface,
and are embedded in an extracellular matrix produced by the bacteria and/or derived from …

Bacterial biofilms: a diagnostic and therapeutic challenge

CA Fux, P Stoodley, L Hall-Stoodley… - Expert review of anti …, 2003 - Taylor & Francis
Bacteria have traditionally been regarded as individual organisms growing in homogeneous
planktonic populations. However, bacteria in natural environments usually form communities …

Approaches to biofilm-associated infections: the need for standardized and relevant biofilm methods for clinical applications

M Malone, DM Goeres, I Gosbell, K Vickery… - Expert review of anti …, 2017 - Taylor & Francis
Introduction: The concept of biofilms in human health and disease is now widely accepted
as cause of chronic infection. Typically, biofilms show remarkable tolerance to many forms of …

Options and limitations in clinical investigation of bacterial biofilms

M Magana, C Sereti, A Ioannidis… - Clinical Microbiology …, 2018 - Am Soc Microbiol
Bacteria can form single-and multispecies biofilms exhibiting diverse features based upon
the microbial composition of their community and microenvironment. The study of bacterial …

MBEC versus MBIC: the lack of differentiation between biofilm reducing and inhibitory effects as a current problem in biofilm methodology

L Thieme, A Hartung, K Tramm… - Biological procedures …, 2019 - Springer
Background Biofilms are communities of aggregated, matrix-embedded microbial cells
showing a high tolerance to an in principle adequate antibiotic therapy, often resulting in …

Diagnosis of biofilm infections: Current methods used, challenges and perspectives for the future

NBS Silva, LA Marques… - Journal of Applied …, 2021 - academic.oup.com
The diagnosis of biofilms continues to be a challenge, and there is no standardized protocol
for such a diagnosis in clinical practice. In addition, some proposed methodologies are …

Biofilms, medical devices, and antibiofilm technology: Key messages from a recent public workshop

KS Phillips, D Patwardhan, G Jayan - American journal of infection …, 2015 - ajicjournal.org
The public health (PH) impact of microbial colonization and biofilm formation on medical
devices has received considerable attention over the last decade. According to a 2002 …

Strategies for combating antibiotic resistance in bacterial biofilms

KE Grooters, JC Ku, DM Richter, MJ Krinock… - Frontiers in Cellular …, 2024 - frontiersin.org
Biofilms, which are complexes of microorganisms that adhere to surfaces and secrete
protective extracellular matrices, wield substantial influence across diverse domains such as …

Towards diagnostic guidelines for biofilm-associated infections

L Hall-Stoodley, P Stoodley, S Kathju… - FEMS Immunology & …, 2012 - academic.oup.com
Biofilms associated with the human body, particularly in typically sterile locations, are difficult
to diagnose and treat effectively because of their recalcitrance to conventional antibiotic …