Apoptosis in response to cellular stress such as treatment with cytotoxic drugs is mediated
by effector caspases (caspase-3) which can be activated by different initiator pathways …

The molecular mechanism underlying chemotherapy-induced apoptosis is often debated
because of contradicting reports of its signaling pathway. The focus of this ongoing debate is …

Caspase-8 is a key effector of death-receptor-triggered apoptosis. In a previous study, we
demonstrated, however, that caspase-8 can also be activated in a death receptor …

Chemotherapy-induced apoptosis is generally thought to be dependent on a pathway
headed by caspase-9. This model is primarily based on studies performed in leukemia cells; …

Apoptosis mediated by anticancer drugs may involve activation of death-inducing
ligand/receptor systems such as CD95 (APO-1/Fas), cleavage of caspases, and perturbance …

Apoptosis is induced by different stimuli, among them triggering of the death receptor CD95,
staurosporine, and chemotherapeutic drugs. In all cases, apoptosis is mediated by …

Studies performed over the past five years have demonstrated that there are two major cell-
intrinsic pathways for inducing apoptosis, one that begins with ligation of cell surface death …

▪ Abstract Caspase activation plays a central role in the execution of apoptosis. The key
components of the biochemical pathways of caspase activation have been recently …

Recently, caspase-2 was shown to act upstream of mitochondria in stress-induced
apoptosis. Activation of caspase-8, a key event in death receptor-mediated apoptosis, also …

Apoptosis and necrosis are two distinct forms of cell death. Caspases are indispensable as
initiators and effectors of apoptotic cell death and are involved in many of the morphological …