Infant B-cell acute lymphoblastic leukemia (B-ALL) accounts for 10% of childhood ALL. The
genetic hallmark of most infant B-ALL is chromosomal rearrangements of the mixed-lineage …

Over 90% of infants (< 1‐year‐old) diagnosed with leukemia have pro‐B acute
lymphoblastic leukemia (ALL) containing the MLL‐AF4 fusion. When compared with other …

Compared with acute lymphoblastic leukemia (ALL) in older children, ALL in infants has a
dismal outcome because rearrangements of the mixed-lineage leukemia (MLL) gene occur …

Infant acute lymphoblastic leukemia (ALL) involving mixed-lineage leukemia (MLL) fusions
has attracted a huge interest in basic and clinical research because of its prenatal origin …

Acute lymphoblastic leukemia (ALL) in infants less than 1 year of age is rare and the
biological features are different from ALL in older children. 1 Infant ALL is characterized by a …

The pathogenesis of infant acute lymphoblastic leukemia (ALL) is still not well defined. Short
latency to leukemia and very high concordance rate for ALL in Mixed-Lineage Leukemia …

B-cell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell
acute lymphoblastic leukemia remains fatal, especially in patients with t (4; 11), present in …

The most common chromosomal abnormality of infant acute lymphoblastic leukemia (ALL) is
the t (4; 11)(q21; q23) that gives rise to the MLL/AF4 fusion gene. Leukemic blasts …

Infant ALL is uncommon, biologically distinctive from the disease in older children, and
associated with a relatively poor prognosis. Adverse prognostic factors include the presence …

Acute lymphoblastic leukemia (ALL) in infants (< 1 year) is characterized by a poor
prognosis and a high incidence of MLL translocations. Several studies demonstrated the …