Kidneys possess one of the most intricate three-dimensional cellular structures in the body,
yet the spatial and molecular principles of kidney health and disease remain inadequately …

Available transcriptomes of the mammalian kidney provide limited information on the spatial
interplay between different functional nephron structures due to the required dissociation of …

The human kidney is a complex organ composed of specialized cell types. To better define
this cellular complexity, we profiled the individual transcriptomes of 22,469 normal human …

Kidney Precision Medicine Project (KPMP) is building a spatially specified human kidney
tissue atlas in health and disease with single-cell resolution. Here, we describe the …

The kidney's cellular diversity is on par with its physiological intricacy; yet identifying cell
populations and their markers remains challenging. Here, we created a comprehensive …

Diabetic kidney disease (DKD) develops in~ 40% of patients with diabetes and is the
leading cause of chronic kidney disease worldwide. We used single‐cell RNA‐sequencing …

Defining changes in gene expression during health and disease is critical for the
understanding of human physiology. In recent years, single-cell/nuclei RNA sequencing …

Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease, resulting
in a huge socio-economic impact. Kidney is a highly complex organ and the pathogenesis …

Understanding kidney disease relies on defining the complexity of cell types and states, their
associated molecular profiles and interactions within tissue neighbourhoods. Here we …

Kidney disease represents a global health burden of increasing prevalence and is an
independent risk factor for cardiovascular disease. Myeloid cells are a major cellular …