Aims Crosstalk between cardiomyocytes and fibroblasts in physiological conditions and
during disease remains poorly defined. Previous studies have shown that fibroblasts and …

Cardiac fibroblasts impact myocardial development and remodeling through intercellular
contact with cardiomyocytes, but less is known about noncontact, profibrotic signals whereby …

Cardiac fibroblasts are emerging as key components of normal cardiac function, as well as
the response to stressors and injury. These most numerous cells of the heart interact with …

Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix
in the heart, providing support to the contracting myocardium and contributing to a myriad of …

The cytoarchitecture of the working myocardium is characterized by densely packed
cardiomyocytes that are embedded in a three-dimensional network of numerous fibroblasts …

The cardiac extracellular matrix (ECM) is a dynamic structure, adapting to physiological and
pathological stresses placed on the myocardium. Deposition and organization of the matrix …

Interspersed between cardiac myocytes, cardiac fibroblasts serve mainly as a structural
support during ventricular wall thickening from embryogenesis until adulthood. Cardiac …

Cardiac fibroblasts are the most prevalent cell type in the heart and play a key role in
regulating normal myocardial function and in the adverse myocardial remodeling that occurs …

The cardiac fibroblast (CF) has historically been thought of as a quiescent cell of the heart,
passively maintaining the extracellular environment for the cardiomyocytes (CM), the …

Under normal physiological conditions, cardiac fibroblasts are the primary producers of
extracellular matrix and supply a mechanical scaffold for efficacious heart contractions …