Inactivation of the p53 tumor suppressor is a frequent event in tumorigenesis. In most cases,
the p53 gene is mutated, giving rise to a stable mutant protein whose accumulation is …

The key role of p53 as a tumor suppressor became clear when it was realized that this gene
is mutated in 50% of human sporadic cancers, and germline mutations expose carriers to …

P53 is often mutated in solid tumors, in fact, somatic changes involving the gene encoding
for p53 (TP53) have been discovered in more than 50% of human malignancies and several …

Inactivation of tumor-suppressor genes is one of the key hallmarks of a tumor. Unlike other
tumor-suppressor genes, p53 is inactivated by missense mutations in half of all human …

The tumor suppressor p53 plays a central role in the protection against DNA damage and
other forms of physiological stress primarily by inducing cell cycle arrest or apoptosis …

The strongest and undisputed fact about p53 is the high frequency of p53 alterations in
human cancer and that mutant p53 proteins constitute a complex family of several hundred …

The tumor suppressor protein p53 plays a critical role in limiting malignant development and
progression. Almost all cancers show loss of p53 function, through either mutation in the p53 …

The p53 protein is a transcription factor known as the" guardian of the genome" because of
its critical function in preserving genomic integrity. The TP53 gene is mutated in …

Many different types of cancer show a high incidence of TP53 mutations, leading to the
expression of mutant p53 proteins. There is growing evidence that these mutant p53s have …

Thirty-five years of research on p53 gave rise to more than 68,000 articles and reviews, but
did not allow the uncovering of all the mysteries that this major tumor suppressor holds. How …