Pre-extinction administration of Δ 9-tetrahydrocannibinol (THC) facilitates recall of extinction
in healthy humans, and evidence from animal studies suggest that this likely occurs via …

Endocannabinoids are critically involved in the extinction of fear memory. Here we
examined the effects of repeated cannabinoid administration on the extinction of fear …

A first-line approach to treat anxiety disorders is exposure-based therapy, which relies on
extinction processes such as repeatedly exposing the patient to stimuli (conditioned stimuli; …

Anxiety disorders, such as post-traumatic stress (PTSD), panic, and phobic disorders, can be
conceptualized as a failure to inhibit inappropriate fear responses. A common, effective …

The neural mechanisms and durability of Δ9-tetrahydrocannabinol (THC) impact on threat
processing in humans are not fully understood. Herein, we used functional MRI and …

Previous studies have implicated cannabinoids in extinction of conditioned fear. We have
recently showed that intraventricular infusion of the phytocannabinoid cannabidiol (CBD) …

Despite the fact that the cannabinoid receptor type 1 (CB1R) plays a pivotal role in
emotional memory processing in different regions of the brain, its function in the retrosplenial …

Background: Δ9-Tetrahydrocannabinol (THC, a CB1 receptor agonist) and Cannabidiol
(CBD, a non-competitive antagonist of endogenous CB1 and CB2 ligands) are two primary …

Abstract Δ 9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are the major constituents
of the Cannabis sativa plant, which is frequently consumed by subjects exposed to life …

The prefrontal cortex (PFC), amygdala and hippocampus display a coordinated activity
during acquisition of associative fear memories. Evidence indicates that PFC engagement in …