The role of type I interferon in the treatment of COVID‐19

F Sodeifian, M Nikfarjam, N Kian… - Journal of medical …, 2022 - Wiley Online Library
Although significant research has been done to find effective drugs against coronavirus
disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 …

[HTML][HTML] Roles of Type I and III Interferons in COVID-19

H Choi, EC Shin - Yonsei medical journal, 2021 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I and III interferon …

Type 1 interferons as a potential treatment against COVID-19

E Sallard, FX Lescure, Y Yazdanpanah, F Mentre… - Antiviral research, 2020 - Elsevier
Type 1 interferons have a broad antiviral activity in vitro and are currently evaluated in a
clinical trial to treat MERS-CoV. In this review, we discuss preliminary data concerning the …

Potential role of interferons in treating COVID-19 patients

MH Abdolvahab, S Moradi-Kalbolandi, M Zarei… - International …, 2021 - Elsevier
The recently public health crises in the world is emerged by spreading the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) also named COVID-19. The virus is …

[HTML][HTML] Current utilization of interferon alpha for the treatment of coronavirus disease 2019: A comprehensive review

LY Lu, PH Feng, MS Yu, MC Chen, AJH Lin… - Cytokine & Growth …, 2022 - Elsevier
Recent studies have identified an association between perturbed type I interferon (IFN)
responses and the severity of coronavirus disease 2019 (COVID-19). IFNα intervention may …

Downregulation of type III interferons in patients with severe COVID‐19

Y Fukuda, T Homma, H Inoue… - Journal of medical …, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) is globally rampant, and to curb the growing
burden of this disease, in‐depth knowledge about its pathophysiology is needed. This was …

Antiviral activities of type I interferons to SARS-CoV-2 infection

E Mantlo, N Bukreyeva, J Maruyama, S Paessler… - Antiviral research, 2020 - Elsevier
There is an urgent need to identify antivirals to curtail the COVID-19 pandemic. Herein, we
report the sensitivity of SARS-CoV-2 to recombinant human interferons α and β (IFNα/β) …

[HTML][HTML] Dual nature of type I interferons in SARS-CoV-2-induced inflammation

C King, J Sprent - Trends in immunology, 2021 - cell.com
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). The ability of our cells to secrete type I …

Subcutaneous administration of interferon beta-1a for COVID-19: A non-controlled prospective trial

F Dastan, SA Nadji, A Saffaei, M Marjani… - International …, 2020 - Elsevier
Background Recently, a new coronavirus spreads rapidly throughout the countries and
resulted in a worldwide epidemic. Interferons have direct antiviral and immunomodulatory …

Interferon therapy for COVID-19 and emerging infections: Prospects and concerns.

LH Calabrese, T Lenfant… - Cleveland Clinic Journal of …, 2020 - europepmc.org
Numerous immunomodulating agents are currently being studied in clinical trials for the
treatment of COVID-19, including interferon therapies. Interferons are naturally occurring …