Blood biomarkers for mild traumatic brain injury: a selective review of unresolved issues

DB Hier, T Obafemi-Ajayi, MS Thimgan, GR Olbricht… - Biomarker …, 2021 - Springer
Background The use of blood biomarkers after mild traumatic brain injury (mTBI) has been
widely studied. We have identified eight unresolved issues related to the use of five …

The known unknowns: an overview of the state of blood-based protein biomarkers of mild traumatic brain injury

SJ McDonald, SR Shultz, DV Agoston - Journal of Neurotrauma, 2021 - liebertpub.com
Blood-based protein biomarkers have revolutionized several fields of medicine by enabling
molecular level diagnosis, as well as monitoring disease progression and treatment efficacy …

Blood biomarkers for brain injury: What are we measuring?

K Kawata, CY Liu, SF Merkel, SH Ramirez… - Neuroscience & …, 2016 - Elsevier
Accurate diagnosis for mild traumatic brain injury (mTBI) remains challenging, as prognosis
and return-to-play/work decisions are based largely on patient reports. Numerous …

[HTML][HTML] Exploring serum biomarkers for mild traumatic brain injury

L Papa, D Edwards, M Ramia - 2015 - europepmc.org
The diagnosis of traumatic brain injury (TBI) in the acute setting is based on neurological
examination and neuroimaging tools such as CT scanning and MRI. However, CT scanning …

Blood biomarkers in moderate-to-severe traumatic brain injury: potential utility of a multi-marker approach in characterizing outcome

AP Di Battista, JE Buonora, SG Rhind… - Frontiers in …, 2015 - frontiersin.org
Background Blood biomarkers are valuable tools for elucidating complex cellular and
molecular mechanisms underlying traumatic brain injury (TBI). Profiling distinct classes of …

Biomarkers of traumatic brain injury: temporal changes in body fluids

H Adrian, K Mårten, N Salla, V Lasse - Eneuro, 2016 - eneuro.org
Traumatic brain injuries (TBIs) are caused by a hit to the head or a sudden acceleration/
deceleration movement of the head. Mild TBIs (mTBIs) and concussions are difficult to …

Blood biomarkers for traumatic brain injury: a quantitative assessment of diagnostic and prognostic accuracy

ZS Gan, SC Stein, R Swanson, S Guan… - Frontiers in …, 2019 - frontiersin.org
Blood biomarkers have been explored for their potential to provide objective measures in
the assessment of traumatic brain injury (TBI). However, it is not clear which biomarkers are …

The biological significance and clinical utility of emerging blood biomarkers for traumatic brain injury

ME Huibregtse, JJ Bazarian, SR Shultz… - … & Biobehavioral Reviews, 2021 - Elsevier
Abstract HUIBREGTSE, ME, Bazarian, JJ, Shultz, SR, and Kawata K. The biological
significance and clinical utility of emerging blood biomarkers for traumatic brain injury …

The challenge of mild traumatic brain injury: role of biochemical markers in diagnosis of brain damage

S Mondello, K Schmid, RP Berger… - Medicinal research …, 2014 - Wiley Online Library
During the past decade there has been an increasing recognition of the incidence of mild
traumatic brain injury (mTBI) and a better understanding of the subtle neurological and …

A blood-based biomarker panel to risk-stratify mild traumatic brain injury

R Sharma, A Rosenberg, ER Bennett, DT Laskowitz… - PloS one, 2017 - journals.plos.org
Mild traumatic brain injury (TBI) accounts for the vast majority of the nearly two million brain
injuries suffered in the United States each year. Mild TBI is commonly classified as …