Background There is an urgent need to identify factors that increase vulnerability to opioid
addiction to help stem the opioid epidemic and develop more efficient …

Non-coding RNAs (ncRNAs), especially microRNAs, are reported to be involved in a variety
of biological processes, including several processes related to drug addiction. It has been …

Although previous animal studies have indicated that certain micro ribonucleic acids
(microRNAs) play a part in the pathway of opioid addiction, whether such findings extend to …

A powerful motivation to seek opioids remains after drug cessation and intensifies during
extended periods of abstinence. Unfortunately, biomarkers associated with continued drug …

Drug addiction is considered a disorder of neuroplasticity in brain reward and cognition
systems resulting from aberrant activation of gene expression programs in response to …

Abstract μ-Opioid receptor (MOR) level is directly related to the function of opioid drugs, such
as morphine and fentanyl. Although agonist treatment generally does not affect transcription …

When we talk about drug addiction, we are really dealing with an extremely complex system
in which there still remain many unknowns and where many empty spaces or missing links …

Opioid misuse in the United States contributes to> 70% of annual overdose deaths. To
develop additional therapeutics that may prevent opioid misuse, further studies on the …

Opioid use disorder (OUD) is a chronic condition associated with long-lasting molecular and
behavioral changes. Animals with prolonged access to opioids develop behaviors similar to …

Abstract Changes in microRNA (miRNA)-mediated gene expression in the nucleus
accumbens (NAc) may play important roles in regulating drug addiction. MiR-29c is a highly …