H Zheng, PY Law, HH Loh - Frontiers in Genetics, 2012 - frontiersin.org
Non-coding RNAs (ncRNAs), especially microRNAs, are reported to be involved in a variety of biological processes, including several processes related to drug addiction. It has been …
CW Hsu, TL Huang, MC Tsai - Journal of clinical medicine, 2019 - mdpi.com
Although previous animal studies have indicated that certain micro ribonucleic acids (microRNAs) play a part in the pathway of opioid addiction, whether such findings extend to …
A Gillespie, HL Mayberry, ME Wimmer… - European Journal of …, 2022 - Wiley Online Library
A powerful motivation to seek opioids remains after drug cessation and intensifies during extended periods of abstinence. Unfortunately, biomarkers associated with continued drug …
P Bali, PJ Kenny - Frontiers in genetics, 2013 - frontiersin.org
Drug addiction is considered a disorder of neuroplasticity in brain reward and cognition systems resulting from aberrant activation of gene expression programs in response to …
Q Wu, CK Hwang, H Zheng, Y Wagley, HY Lin… - The FASEB …, 2013 - ncbi.nlm.nih.gov
Abstract μ-Opioid receptor (MOR) level is directly related to the function of opioid drugs, such as morphine and fentanyl. Although agonist treatment generally does not affect transcription …
RE Rodríguez - Frontiers in Genetics, 2012 - frontiersin.org
When we talk about drug addiction, we are really dealing with an extremely complex system in which there still remain many unknowns and where many empty spaces or missing links …
MT Zanda, L Saikali, P Morris… - Advances in Drug and …, 2023 - frontierspartnerships.org
Opioid misuse in the United States contributes to> 70% of annual overdose deaths. To develop additional therapeutics that may prevent opioid misuse, further studies on the …
Opioid use disorder (OUD) is a chronic condition associated with long-lasting molecular and behavioral changes. Animals with prolonged access to opioids develop behaviors similar to …
H Su, L Zhu, J Li, R Wang, D Liu, W Han, JL Cadet… - …, 2019 - Elsevier
Abstract Changes in microRNA (miRNA)-mediated gene expression in the nucleus accumbens (NAc) may play important roles in regulating drug addiction. MiR-29c is a highly …