Inflammation and hypertension: the interplay of interleukin-6, dietary sodium, and the renin–angiotensin system in humans

B Chamarthi, GH Williams, V Ricchiuti… - American journal of …, 2011 - academic.oup.com
Background Prior evidence suggests a link between inflammation and hypertension.
Interleukin-6 (IL-6) has been implicated in animal studies to play an important role in …

Deletion of interleukin-6 prevents cardiac inflammation, fibrosis and dysfunction without affecting blood pressure in angiotensin II-high salt-induced hypertension

GE González, NE Rhaleb, MA D'ambrosio… - Journal of …, 2015 - journals.lww.com
Objective: Inflammation has been proposed as a key component in the development of
hypertension and cardiac remodeling associated with different cardiovascular diseases …

Angiotensin II hypertension is attenuated in interleukin-6 knockout mice

DL Lee, LC Sturgis, H Labazi… - American Journal …, 2006 - journals.physiology.org
Plasma levels of IL-6 correlate with high blood pressure under many circumstances, and
ANG II has been shown to stimulate IL-6 production from various cell types. This study tested …

Lowering of blood pressure leads to decreased circulating interleukin-6 in hypertensive subjects

G Vazquez-Oliva, JM Fernandez-Real… - Journal of human …, 2005 - nature.com
Abstract Interleukin-6 (IL-6), the major proinflammatory cytokine, has been described to be
associated with the hypertensive and atherosclerotic states. We aimed to explore whether …

Arterial hypertension and interleukins: potential therapeutic target or future diagnostic marker?

DM Tanase, EM Gosav, S Radu… - International journal …, 2019 - Wiley Online Library
Hypertension as a multifactorial pathology is one of the most important cardiovascular risk
factors, affecting up to 30‐40% of the general population. Complex immune responses are …

Is hypertension an inflammatory disease?

JJ Li, CH Fang, RT Hui - Medical hypotheses, 2005 - Elsevier
Hypertension has been recognized as a multi-factorial trait resulting from the effect of a
combination of environmental and genetic factors, including excess dietary salt or alcohol …

Angiotensin II induces interleukin-6 in humans through a mineralocorticoid receptor–dependent mechanism

JM Luther, JV Gainer, LJ Murphey, C Yu… - …, 2006 - Am Heart Assoc
This study tested the hypothesis that angiotensin promotes oxidative stress and
inflammation in humans via aldosterone and the mineralocorticoid receptor. We measured …

An emerging role for inflammatory cytokines in hypertension

JP Granger - American Journal of Physiology-Heart and …, 2006 - journals.physiology.org
EPIDEMIOLOGICAL and experimental studies have revealed an association between
biochemical markers of systemic inflammation and cardiovascular disease such as …

Blood pressure and inflammation in apparently healthy men

CU Chae, RT Lee, N Rifai, PM Ridker - Hypertension, 2001 - Am Heart Assoc
Inflammation plays an important role in the development of atherosclerosis, but the specific
stimuli governing cytokine release in atherogenesis are unknown. We examined the …

Inflammation as a regulator of the renin-angiotensin system and blood pressure

R Satou, H Penrose, LG Navar - Current hypertension reports, 2018 - Springer
Abstract Purpose of Review Mechanisms facilitating progression of hypertension via cross
stimulation of the renin-angiotensin system (RAS) and inflammation have been proposed …