Macrophages are the first immune cells in the developing embryo and have a central role in organ development, homeostasis, immunity and repair. Over the last century, our …
TA Wynn, A Chawla, JW Pollard - Nature, 2013 - nature.com
Macrophages, the most plastic cells of the haematopoietic system, are found in all tissues and show great functional diversity. They have roles in development, homeostasis, tissue …
M Haldar, KM Murphy - Immunological reviews, 2014 - Wiley Online Library
Macrophages are versatile cells of the hematopoietic system that display remarkable functional diversity encompassing innate immune responses, tissue development, and …
N Cox, M Pokrovskii, R Vicario… - Annual review of …, 2021 - annualreviews.org
Tissue-resident macrophages are present in most tissues with developmental, self-renewal, or functional attributes that do not easily fit into a textbook picture of a plastic and …
Highlights•We review the potential impact of cellular origin on the function of macrophages.•We discuss the recent evidence for macrophages plasticity.•We also highlight …
Macrophages have protective roles in immunity to pathogens, tissue development, homeostasis and repair following damage. Maladaptive immunity and inflammation provoke …
C Varol, A Mildner, S Jung - Annual review of immunology, 2015 - annualreviews.org
Macrophages are myeloid immune cells that are strategically positioned throughout the body tissues, where they ingest and degrade dead cells, debris, and foreign material and …
Macrophages are innate immune cells that form a 3D network in all our tissues, where they phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …
A Dey, J Allen, PA Hankey-Giblin - Frontiers in immunology, 2015 - frontiersin.org
The explosion of new information in recent years on the origin of macrophages in the steady- state and in the context of inflammation has opened up numerous new avenues of …