The β-lactam antibiotics have long been a cornerstone for the treatment of bacterial disease.
Recently, a readily transferable antibiotic resistance factor called the New Delhi metallo-β …

The New Delhi Metallo-β-lactamase (NDM-1) gene makes multiple pathogenic
microorganisms resistant to all known β-lactam antibiotics. The rapid emergence of NDM-1 …

Abstract β‐Lactams are the most commonly prescribed class of antibiotics and have had an
enormous impact on human health. Thus, it is disquieting that an enzyme called New Delhi …

The worldwide emergence of New Delhi metallo-β-lactamase-1 (NDM-1) as a
carbapenemase able to hydrolyze nearly all available β-lactam antibiotics has characterized …

New Delhi metallo-β-lactamases (NDMs), the recent additions to metallo-β-lactamases
(MBLs), pose a serious public health threat due to its highly efficient hydrolysis of β-lactam …

New Delhi metallo-beta-lactamase (NDM-1) is an enzyme that makes bacteria resistant to a
broad range of beta-lactam antibiotic drugs. This is because it can inactivate most beta …

This past year has produced determinations of X-ray crystal structures for three metallo-β-
lactamases and the elucidation of the catalytic mechanisms for a monozinc and a dizinc …

ABSTRACT Metallo‐β‐lactamases (MBLs) hydrolyze most β‐lactam antibiotics, and bacteria
containing this kind of enzyme pose a serious threat to the public health. The newly …

Metallo-β-lactamases are the latest resistance mechanism of pathogenic and opportunistic
bacteria against carbapenems, considered as last resort drugs. The worldwide spread of …

Metallo-β-lactamases are zinc-dependent enzymes responsible for resistance to β-lactam
antibiotics in a variety of host bacteria, usually Gram-negative species that act as opportunist …