Piceatannol promotes neuroprotection by inducing mitophagy and mitobiogenesis in the experimental diabetic peripheral neuropathy and hyperglycemia-induced …
Abstract Piceatannol (PCN), a SIRT1 activator, regulates multiple oxidative stress
mechanism and has anti-inflammatory potential in various inflammatory conditions …
mechanism and has anti-inflammatory potential in various inflammatory conditions …
Activation of SIRT1 by silibinin improved mitochondrial health and alleviated the oxidative damage in experimental diabetic neuropathy and high glucose-mediated …
Background Silibinin (SBN), a sirtuin 1 (SIRT1) activator, has been evaluated for its anti-
inflammatory activity in many inflammatory diseases. However, its role in diabetes-induced …
inflammatory activity in many inflammatory diseases. However, its role in diabetes-induced …
SIRT1 activation by polydatin alleviates oxidative damage and elevates mitochondrial biogenesis in experimental diabetic neuropathy
P Bheereddy, VG Yerra, AK Kalvala… - Cellular and molecular …, 2021 - Springer
Mitochondrial dysfunction has been implicated as a one of the major factors linked to the
development of painful diabetic neuropathy (DN). Several studies have demonstrated that …
development of painful diabetic neuropathy (DN). Several studies have demonstrated that …
Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy
Sirtuin (SIRT1) inactivation underlies the pathogenesis of insulin resistance and
hyperglycaemia-associated vascular complications, but its role in diabetic neuropathy (DN) …
hyperglycaemia-associated vascular complications, but its role in diabetic neuropathy (DN) …
Quercetin Attenuates Diabetic Peripheral Neuropathy by Correcting Mitochondrial Abnormality via Activation of AMPK/PGC-1α Pathway in vivo and in vitro
Q Zhang, W Song, B Zhao, J Xie, Q Sun, X Shi… - Frontiers in …, 2021 - frontiersin.org
The AMPK/PGC-1α pathway-mediated mitochondrial dysfunction has been supposed to
play a crucial role in pathogenesis of diabetic peripheral neuropathy (DPN). The present …
play a crucial role in pathogenesis of diabetic peripheral neuropathy (DPN). The present …
Artesunate inhibits apoptosis and promotes survival in schwann cells via the PI3K/AKT/mTOR axis in diabetic peripheral neuropathy
X Zhang, Z Liang, Y Zhou, F Wang, S Wei… - Biological and …, 2023 - jstage.jst.go.jp
Diabetic peripheral neuropathy (DPN) is an early developing complication of diabetes
mellitus associated with nerve dysfunction. Artesunate (ART), a natural compound extracted …
mellitus associated with nerve dysfunction. Artesunate (ART), a natural compound extracted …
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of vidarabine against rotenone-induced neural cell injury
L Li, Y Zhang, Z Chen, R Yao, Z Xu, C Xu, F He, H Pei… - Heliyon, 2023 - cell.com
Parkinson's disease (PD) is the second most common neurodegenerative disease in the
world, which is distinguished by the loss of dopaminergic (DA) neurons in the substantia …
world, which is distinguished by the loss of dopaminergic (DA) neurons in the substantia …
S1PR2 inhibition mitigates cognitive deficit in diabetic mice by modulating microglial activation via Akt-p53-TIGAR pathway
Cognitive deficit is one of the challenging complications of type 2 diabetes. Sphingosine 1-
phosphate receptors (S1PRs) have been implicated in various neurodegenerative and …
phosphate receptors (S1PRs) have been implicated in various neurodegenerative and …
Resveratrol ameliorates podocyte damage in diabetic mice via SIRT1/PGC‐1α mediated attenuation of mitochondrial oxidative stress
T Zhang, Y Chi, Y Kang, H Lu, H Niu… - Journal of cellular …, 2019 - Wiley Online Library
Excessive generation of mitochondrial reactive oxygen species (ROS) is considered to be
initiating event in the development of diabetic nephropathy (DN). Mitochondrial biosynthesis …
initiating event in the development of diabetic nephropathy (DN). Mitochondrial biosynthesis …
Adenosine monophosphate-activated protein kinase modulation by berberine attenuates mitochondrial deficits and redox imbalance in experimental diabetic …
Adenosine monophosphate-activated protein kinase (AMPK) has been studied for its myriad
metabolic and mitochondrial benefits in several chronic diseases. Recent studies have …
metabolic and mitochondrial benefits in several chronic diseases. Recent studies have …