Detection of SARS-CoV-2 infection in human nasopharyngeal samples by combining MALDI-TOF MS and artificial intelligence

M Deulofeu, E García-Cuesta, EM Peña-Méndez… - Frontiers in …, 2021 - frontiersin.org
The high infectivity of SARS-CoV-2 makes it essential to develop a rapid and accurate
diagnostic test so that carriers can be isolated at an early stage. Viral RNA in …

A combined approach of MALDI-TOF mass spectrometry and multivariate analysis as a potential tool for the detection of SARS-CoV-2 virus in nasopharyngeal swabs

MF Rocca, JC Zintgraff, ME Dattero, LS Santos… - Journal of virological …, 2020 - Elsevier
Coronavirus disease 2019, known as COVID-19, is caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). The early, sensitive and specific detection of SARS …

Exploratory study on application of MALDI-TOF-MS to detect SARS-CoV-2 infection in human saliva

MM Costa, H Martin, B Estellon, FX Dupé… - Journal of Clinical …, 2022 - mdpi.com
SARS-CoV-2 has caused a large outbreak since its emergence in December 2019. COVID-
19 diagnosis became a priority so as to isolate and treat infected individuals in order to …

MALDI (+) FT-ICR mass spectrometry (MS) combined with machine learning toward saliva-based diagnostic screening for COVID-19

CM de Almeida, LC Motta, GS Folli… - Journal of Proteome …, 2022 - ACS Publications
Rapid identification of existing respiratory viruses in biological samples is of utmost
importance in strategies to combat pandemics. Inputting MALDI FT-ICR MS (matrix-assisted …

Novel application of automated machine learning with MALDI-TOF-MS for rapid high-throughput screening of COVID-19: A proof of concept

NK Tran, T Howard, R Walsh, J Pepper, J Loegering… - Scientific reports, 2021 - nature.com
The 2019 novel coronavirus infectious disease (COVID-19) pandemic caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created an unsustainable …

Detection of SARS-CoV-2 in nasal swabs using MALDI-MS

FM Nachtigall, A Pereira, OS Trofymchuk… - Nature …, 2020 - nature.com
Detection of SARS-CoV-2 using RT–PCR and other advanced methods can achieve high
accuracy. However, their application is limited in countries that lack sufficient resources to …

Matrix-assisted laser desorption and ionization time-of-flight mass spectrometry analysis for the direct detection of SARS-CoV-2 in nasopharyngeal swabs

T Yoshinari, K Hayashi, S Hirose, K Ohya… - Analytical …, 2022 - ACS Publications
The most common diagnostic method used for coronavirus disease-2019 (COVID-19) is real-
time reverse transcription polymerase chain reaction (PCR). However, it requires complex …

Superiority of MALDI-TOF mass spectrometry over real-time PCR for SARS-CoV-2 RNA detection

M Rybicka, E Miłosz, KP Bielawski - Viruses, 2021 - mdpi.com
At present, the RT-PCR test remains the gold standard for early diagnosis of SARS-CoV-2.
Nevertheless, there is growing evidence demonstrating that this technique may generate …

Efficient SARS-CoV-2 detection in unextracted oro-nasopharyngeal specimens by rRT-PCR with the Seegene Allplex™ 2019-nCoV assay

W Freppel, N Merindol, F Rallu, M Bergevin - Virology Journal, 2020 - Springer
Background The fight against the COVID-19 pandemic has created an urgent need to
rapidly detect infected people. The challenge for clinical laboratories has been finding a …

SARS-CoV-2 RNA identification in nasopharyngeal swabs: issues in pre-analytics

D Basso, A Aita, F Navaglia, E Franchin… - Clinical Chemistry and …, 2020 - degruyter.com
Objectives The direct identification of SARS-CoV-2 RNA in nasopharyngeal swabs is
recommended for diagnosing the novel COVID-19 disease. Pre-analytical determinants …