Background Modelling and simulation are being increasingly utilized to support the
discovery and development of new anti-malarial drugs. These approaches require reliable …

Increased efforts in antimalarial drug discovery are urgently needed. The goal must be to
develop safe and affordable new drugs to counter the spread of malaria parasites that are …

Highlights•The antimalarial pipeline has been enriched with new molecules and
targets.•The antimalarial target compound and product profiles have been redefined.•In …

New antimalarial compounds with novel mechanisms of action are urgently needed to
combat the recent rise in antimalarial drug resistance. Phenotypic high-throughput screens …

The emergence of resistance to available antimalarials requires the urgent development of
new medicines. The recent disclosure of several thousand compounds active in vitro against …

The growing resistance to current first-line antimalarial drugs represents a major health
challenge. To facilitate the discovery of new antimalarials, we have implemented an efficient …

Although many new anti-infectives have been discovered and developed solely using
phenotypic cellular screening and assay optimization, most researchers recognize that …

Major advances in our understanding of malaria parasite biology have been made. Coupled
with the completion of the malaria genome, this has presented exciting opportunities for …

It has been recognized that new antimalarials with a novel mode of action are critical to
combat the continued emergence and dissemination of drug-resistant parasites that threaten …

Background In view of the need to continuously feed the pipeline with new anti-malarial
agents adapted to differentiated and more stringent target product profiles (eg, new modes …