Inflammation and aging: signaling pathways and intervention therapies

X Li, C Li, W Zhang, Y Wang, P Qian… - Signal Transduction and …, 2023 - nature.com
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

[HTML][HTML] Chronic inflammation and the hallmarks of aging

JJ Baechle, N Chen, P Makhijani, S Winer… - Molecular …, 2023 - Elsevier
Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Regulation of inflammation as an anti‐aging intervention

J Neves, P Sousa‐Victor - The FEBS journal, 2020 - Wiley Online Library
Aging is accompanied by a decline in physiological integrity and a loss of regenerative
capacity in many tissues. The development of interventions that prevent or reverse age …

Molecular inflammation: underpinnings of aging and age-related diseases

HY Chung, M Cesari, S Anton, E Marzetti… - Ageing research …, 2009 - Elsevier
Recent scientific studies have advanced the notion of chronic inflammation as a major risk
factor underlying aging and age-related diseases. In this review, low-grade, unresolved …

Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

X Zhu, Z Chen, W Shen, G Huang, JM Sedivy… - Signal transduction and …, 2021 - nature.com
Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Low grade inflammation as a common pathogenetic denominator in age-related diseases: novel drug targets for anti-ageing strategies and successful ageing …

G Candore, C Caruso, E Jirillo… - Current …, 2010 - ingentaconnect.com
Nowadays, people are living much longer than they used to do, however they are not free
from ageing. Ageing, an inexorable intrinsic process that affects all cells, tissues, organs and …

Age and age-related diseases: role of inflammation triggers and cytokines

IM Rea, DS Gibson, V McGilligan… - Frontiers in …, 2018 - frontiersin.org
Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

Retracted: chronic inflammation: accelerator of biological aging

B Fougère, E Boulanger, F Nourhashémi… - The Journals of …, 2017 - academic.oup.com
Biological aging is characterized by a chronic low-grade inflammation level. This chronic
phenomenon has been named “inflamm-aging” and is a highly significant risk factor for …

Modern concepts in cardiovascular disease: inflamm-aging

YM Puspitasari, S Ministrini, L Schwarz… - Frontiers in cell and …, 2022 - frontiersin.org
The improvements in healthcare services and quality of life result in a longer life expectancy
and a higher number of aged individuals, who are inevitably affected by age-associated …

[HTML][HTML] Redefining chronic inflammation in aging and age-related diseases: proposal of the senoinflammation concept

HY Chung, DH Kim, EK Lee, KW Chung… - Aging and …, 2019 - ncbi.nlm.nih.gov
Age-associated chronic inflammation is characterized by unresolved and uncontrolled
inflammation with multivariable low-grade, chronic and systemic responses that exacerbate …