Modeling cancer-immune responses to therapy

LG DePillis, A Eladdadi, AE Radunskaya - Journal of pharmacokinetics …, 2014 - Springer
Cancer therapies that harness the actions of the immune response, such as targeted
monoclonal antibody treatments and therapeutic vaccines, are relatively new and promising …

From concept to clinic: Mathematically informed immunotherapy

R Walker, H Enderling - Current Problems in Cancer, 2016 - Elsevier
Mathematical modeling has become a valuable tool in the continued effort to understand,
predict, and ultimately treat a wide range of cancers in recent years. 1, 2 By describing …

Theoretical modeling techniques and their impact on tumor immunology

AL Woelke, MS Murgueitio… - Journal of Immunology …, 2010 - Wiley Online Library
Currently, cancer is one of the leading causes of death in industrial nations. While
conventional cancer treatment usually results in the patient suffering from severe side …

Modeling tumor–immune dynamics

LG de Pillis, AE Radunskaya - … models of tumor-immune system dynamics, 2014 - Springer
Mathematical models of tumor–immune interactions provide an analytical framework in
which to address specific questions regarding tumor–immune dynamics and tumor treatment …

Modeling the dichotomy of the immune response to cancer: cytotoxic effects and tumor-promoting inflammation

KP Wilkie, P Hahnfeldt - Bulletin of mathematical biology, 2017 - Springer
Although the immune response is often regarded as acting to suppress tumor growth, it is
now clear that it can be both stimulatory and inhibitory. The interplay between these …

Mathematical modeling of cancer immunotherapy for personalized clinical translation

JD Butner, P Dogra, C Chung, R Pasqualini… - Nature computational …, 2022 - nature.com
Encouraging advances are being made in cancer immunotherapy modeling, especially in
the key areas of developing personalized treatment strategies based on individual patient …

Employing dynamical computational models for personalizing cancer immunotherapy

Z Agur, K Halevi-Tobias, Y Kogan… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Recently, cancer immunotherapy has shown considerable success, but due to
the complexity of the immune-cancer interactions, clinical outcomes vary largely between …

Optimal control analysis of combined chemotherapy-immunotherapy treatment regimens in a PKPD cancer evolution model

A Bukkuri - Biomath, 2020 - biomath.math.bas.bg
The author constructs a mathematical model capturing tumor-immune dynamics,
incorporating the evolution of drug resistance, pharmacokinetics and pharmacodynamics of …

Immuno-kinetics of immunotherapy: dosing with DCs

E Köse, S Moore, C Ofodile… - Letters in …, 2017 - lettersinbiomath.org
Therapeutic vaccines play a large role in the cast of immunotherapies that are now an
essential component in most cancer treatment regimes. The complexity of the immune …

Addressing current challenges in cancer immunotherapy with mathematical and computational modelling

A Konstorum, AT Vella, AJ Adler… - Journal of the …, 2017 - royalsocietypublishing.org
The goal of cancer immunotherapy is to boost a patient's immune response to a tumour. Yet,
the design of an effective immunotherapy is complicated by various factors, including a …