Vitamin D supplementation improves mitochondrial function and reduces inflammation in placentae of obese women

EA Phillips, N Hendricks, M Bucher… - Frontiers in …, 2022 - frontiersin.org
Background About 30% of women entering pregnancy in the US are obese. We have
previously reported mitochondrial dysregulation and increased inflammation in the …

[HTML][HTML] Placental vitamin D metabolism and its associations with circulating vitamin D metabolites in pregnant women

H Park, MR Wood, OV Malysheva, S Jones… - The American journal of …, 2017 - Elsevier
Background Little is known about placental vitamin D metabolism and its impact on maternal
circulating vitamin D concentrations in humans. Objective This study sought to advance the …

High-Dose Vitamin D Supplementation Significantly Affects the Placental Transcriptome

AL Vestergaard, MK Andersen, RV Olesen, P Bor… - Nutrients, 2023 - mdpi.com
Vitamin D deficiency is a highly prevalent obstetrical concern associated with an increased
risk of complications like pre-eclampsia, gestational diabetes, and growth retardation …

Gestational vitamin D deficiency causes placental insufficiency and fetal intrauterine growth restriction partially through inducing placental inflammation

YH Chen, ZB Liu, L Ma, ZC Zhang, L Fu, Z Yu… - The Journal of Steroid …, 2020 - Elsevier
Several epidemiological studies suggest an association between vitamin D deficiency
(VDD) and fetal intrauterine growth restriction (IUGR). Here, we explored the mechanism …

Does maternal vitamin D status influence placental weight or vascular and inflammatory pathology? Secondary analysis from the Kellogg Pregnancy Study

MJ Mead, CA McWhorter, MD Rodgers… - The Journal of Steroid …, 2023 - Elsevier
Introduction Positive effects of vitamin D (vitD) supplementation on comorbidities of
pregnancy (COP) have been explored; however, few studies have elucidated the …

Relationship between vitamin D and gestational diabetes in overweight or obese pregnant women may be mediated by adiponectin

A Mousa, SK Abell, S Shorakae… - Molecular nutrition & …, 2017 - Wiley Online Library
Scope Maternal vitamin D deficiency has been implicated in adverse pregnancy outcomes.
However, the association between vitamin D and inflammation, particularly adipokines …

Disrupted placental vitamin D metabolism and calcium signaling in gestational diabetes and pre-eclampsia patients

S Varshney, R Adela, G Kachhawa, R Dada… - Endocrine, 2023 - Springer
Introduction Gestational diabetes (GDM) and pre-eclampsia (PE) represents the
unrecognized risk factors for reduced bone content in neonates. The present study is …

Maternal, umbilical arterial and umbilical venous 25‐hydroxyvitamin D and adipocytokine concentrations in pregnancies with and without gestational diabetes

R McManus, K Summers, B De Vrijer… - Clinical …, 2014 - Wiley Online Library
Objective Gestational diabetes mellitus (GDM) has been associated with inflammation as
well as Vitamin D insufficiency. While Vitamin D has anti‐inflammatory properties …

Expressions of vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1, and VDR in placentas from normal and preeclamptic pregnancies

R Ma, Y Gu, S Zhao, J Sun… - American Journal of …, 2012 - journals.physiology.org
Vitamin D insufficiency/deficiency during pregnancy has been linked to increased risk of
preeclampsia. Placenta dysfunction plays an important role in the pathogenesis of this …

Prenatal maternal vitamin D deficiency sex‐dependently programs adipose tissue metabolism and energy homeostasis in offspring

EM Seipelt, F Tourniaire, C Couturier… - The FASEB …, 2020 - Wiley Online Library
In utero environment is crucial to ensure normal development of the fetus and to program
metabolic health throughout the life. Beside macronutrients, the role of micronutrients …