Organic selenocompounds: are they the panacea for human illnesses?

PA Nogara, ME Pereira, CS Oliveira, L Orian… - New Journal of …, 2023 - pubs.rsc.org
The selenium element is essential to some life forms and its biological-chemistry function is
mainly performed by the selenol/selenolate moiety (–SeH/–Se–) in a few selenoproteins …

Toxicology and pharmacology of synthetic organoselenium compounds: An update

CW Nogueira, NV Barbosa, JBT Rocha - Archives of Toxicology, 2021 - Springer
Here, we addressed the pharmacology and toxicology of synthetic organoselenium
compounds and some naturally occurring organoselenium amino acids. The use of …

Organoselenium compounds as mimics of selenoproteins and thiol modifier agents

NV Barbosa, CW Nogueira, PA Nogara… - Metallomics, 2017 - academic.oup.com
Selenium is an essential trace element for animals and its role in the chemistry of life relies
on a unique functional group: the selenol (–SeH) group. The selenol group participates in …

Biological activity of synthetic organoselenium compounds: what do we know about the mechanism

PA Nogara, M Bortoli, L Orian… - Current Chemical …, 2022 - ingentaconnect.com
Low-molecular-mass selenium (LMM-Se) molecules, such as ebselen and
diphenyldiselenide, have many biological and potential therapeutic activities; however, little …

Chemistry and pharmacology of synthetic organoselenium compounds

PA Nogara, CS Oliveira, JBT Rocha - Organoselenium Chemistry, 2020 - degruyter.com
Active support for the importance of selenium (Se) in the cell physiology of mammals was
provided in 1973. Two groups of investigators identified Se as part of the enzyme …

Organoselenium compounds as potential neuroprotective therapeutic agents

W Hassan, CS Oliveira, H Noreen… - Current Organic …, 2016 - ingentaconnect.com
Selenium plays its physiological chemistry in mammalian living cells as the selenol group of
a selenocysteinyl residue found in few numbers of selenoproteins. These proteins have …

[PDF][PDF] Biological and chemical interest in selenium: a brief historical account.

JBT Rocha, BC Piccoli, CS Oliveira - ARKIVOC: Online Journal of …, 2017 - researchgate.net
This review presents a brief account of the discovery, importance, and use of selenium.
Based in the importance of selenoproteins, their mechanism of reaction with the participation …

[图书][B] Organoselenium compounds in biology and medicine: synthesis, biological and therapeutic treatments

VK Jain, KI Priyadarsini - 2017 - books.google.com
Organoselenium shows incredible promise in medicine, particularly cancer therapy. This
book discusses organoselenium chemistry and biology in the context of its therapeutic …

Biochemistry of selenium: a brief overview

CC Reddy, EJ Massaro - Fundamental and Applied Toxicology, 1983 - Elsevier
The chemistry of Se suggests that, in biological systems, it is most likely present as the
selenol (selenomercaptan) R-SeH, or, as the Se ether analogous to sulfur in the amino acid …

Seleno-metabolites and their precursors: a new dawn for several illnesses?

C Morán-Serradilla, E Angulo-Elizari… - Metabolites, 2022 - mdpi.com
Selenium (Se) is an essential element for human health as it is involved in different
physiological functions. Moreover, a great number of Se compounds can be considered …