Converging clinical, biochemical, postmortem, and neuroimaging evidence suggests that
depression is unlikely to be a disease of a single brain region or neurotransmitter system …

Objective: To examine the progress of positron emission tomography (PET) as a tool for
understanding the psychobiology of mood disorders, particularly major depression and …

Single photon emission computed tomography (SPECT) and positron emission tomography
(PET) studies are yielding a picture of clinical depression as a disorder associated with …

BACKGROUND: Depression has a lifetime prevalence of up to 20%. Neuroimaging methods
have revealed various structural and functional changes that occur in a human brain during …

Several studies suggested the neural networks modulating aspects of emotional behaviour
to be implicated in the pathophysiology of mood disorders. These networks involve the …

Depressed individuals show impaired performance in tests of attention and concentration.
They also exhibit PET resting state abnormalities in dorsal prefrontal cortex and anterior …

Abstract to illustrate the types of experimental strategies that are useful in PET [positron
emission tomography] investigations of emotional disorders, we highlight our studies of …

The in vivo study of receptor binding potential in the human brain is made possible by
positron emission tomography (PET) imaging. Here we review PET studies of neuroreceptor …

We performed a systematic review and meta-analysis of neural predictors of response to the
most commonly used, evidence based treatments in clinical practice, namely …

Major depressive disorder (MDD) is a significant cause of morbidity and mortality worldwide,
correlating with genetic susceptibility and environmental risk factors. Molecular, functional …