Objective Drug‐resistant epilepsy causes great clinical danger and still lacks effective
treatments. Methods Here, we used multifaceted approaches combining electrophysiology …

Neurons continuously adapt the expression and functionality of their ion channels. For
example, exposed to chronic excitotoxicity, neurons homeostatically downscale their …

Objective Unidentified mechanisms largely restrict the viability of effective therapies in
pharmacoresistant epilepsy. Our previous study revealed that hyperactivity of the subiculum …

Purpose: Most patients who are resistant to the first antiepileptic drug (AED) treatment are
also resistant to a treatment with a second or third AED, indicating that patients who have an …

Temporal lobe epilepsy (TLE) is the most common type of epilepsy and is often medically
refractory. Previous studies suggest that selective pharmaco-genetic inhibition of pyramidal …

The most researched brain region in epilepsy research is the temporal lobe, and more
specifically, the hippocampus. However, numerous other brain regions play a pivotal role in …

Epilepsy is a common neurological disease. About 30% of epileptic patients develop
resistance to antiepileptic drugs (AEDs), and are considered to have refractory or …

Despite the development of many new anti-seizure drugs over the past two decades, around
one-third of individuals with epilepsy are without effective treatment. This …

The development of resistance to pharmacological treatment is common to many human
diseases. In chronic epilepsy, many patients develop resistance to anticonvulsant drug …

Epilepsy is considered a circuit-level dysfunction associated with imbalanced excitation-
inhibition, it is therapeutically necessary to identify key brain regions and related circuits in …