Trait-associated genetic variants affect complex phenotypes primarily via regulatory
mechanisms on the transcriptome. To investigate the genetics of gene expression, we …

Genome-wide association studies have identified thousands of genetic variants that are
associated with disease. Most of these variants have small effect sizes, but their downstream …

In recent years, multiple eQTL (expression quantitative trait loci) catalogs have become
available that can help understand the functionality of complex trait-related single nucleotide …

While many disease-associated variants have been identified through genome-wide
association studies, their downstream molecular consequences remain unclear. To identify …

We apply integrative approaches to expression quantitative loci (eQTLs) from 44 tissues
from the Genotype-Tissue Expression project and genome-wide association study data …

Genetics of gene expression (eQTLs or expression QTLs) has proved an indispensable tool
for understanding biological pathways and pathomechanisms of trait-associated SNPs …

Genetic risk factors often localize to noncoding regions of the genome with unknown effects
on disease etiology,. Expression quantitative trait loci (eQTLs) help to explain the regulatory …

In recent years, functional genomics approaches combining genetic information with bulk
RNA-sequencing data have identified the downstream expression effects of disease …

Genetic variants that modulate gene expression levels play an important role in the etiology
of human diseases and complex traits. Although large-scale eQTL mapping studies routinely …

For many complex traits, genetic variants have been found associated. However, it is still
mostly unclear through which downstream mechanism these variants cause these …