Marine-Derived Cytosine Arabinoside (Ara-C) Inhibits Biofilm Formation by Inhibiting PEL Operon Proteins (Pel A and Pel B) of Pseudomonas aeruginosa: An In …

S Datta, V Singh, S Nag, DN Roy - Molecular Biotechnology, 2024 - Springer
Pseudomonas aeruginosa (P. aeruginosa) is a gram-negative biofilm-forming opportunistic
human pathogen whose vital mechanism is biofilm formation for better survival. PelA and …

Seaweed Metabolites for Targeting Pel Polysaccharide Biosynthesis in Pseudomonas aeruginosa–A Novel Strategy for Biofilm Control

AS Praveen, S Vinitha, VS Vinayalekshmi… - Current Trends in …, 2023 - abap.co.in
Abstract According to the National Institute of Health, more than 80% of microbial infections
are biofilm-associated, including chronic lung, wound and ear infections. Pseudomonas …

Assessing the antibiofilm activity of flavonol esters against Pseudomonas aeruginosa PAO1 biofilm: an in vitro, molecular docking, and molecular dynamics study

AT Benny, EK Radhakrishnan - Journal of Biomolecular Structure …, 2023 - Taylor & Francis
Pseudomonas aeruginosa is one of the opportunistic pathogens that may cause serious
health problems and can produce several virulence factors, which are responsible for …

In silico and in vitro evaluation of the anti-virulence potential of patuletin, a natural methoxy flavone, against Pseudomonas aeruginosa

A Metwaly, MM Saleh, A Alsfouk, IM Ibrahim… - PeerJ, 2024 - peerj.com
This study aimed to investigate the potential of patuletin, a rare natural flavonoid, as a
virulence and LasR inhibitor against Pseudomonas aeruginosa. Various computational …

Response regulator GacA and transcriptional activator RhlR proteins involved in biofilm formation of Pseudomonas aeruginosa are prospective targets for natural lead …

S Skariyachan, R Ravishankar, D Gopal… - Infection, Genetics and …, 2020 - Elsevier
Pseudomonas aeruginosa has become a global concern due to its extreme resistance to
most of the last resort antibiotics. Present study focuses on the screening of potential …

Unveiling the Potential of Algal Extracts as Promising Antibacterial and Antibiofilm Agents against Multidrug-Resistant Pseudomonas aeruginosa: In Vitro and In Silico …

S El-Sapagh, R El-Shenody, L Pereira, M Elshobary - Plants, 2023 - mdpi.com
Multidrug-resistant Pseudomonas aeruginosa poses a global challenge due to its virulence
and biofilm-forming ability, leading to persistent infections. This study had a dual focus: first …

Propolis Biomolecules Attenuates Virulence Factors of Multi-Drug Resistant Pseudomonas aeruginosa: In Vitro and In Silico Investigation

W Hadjab, A Zellagui, M Mokrani… - Science of Advanced …, 2024 - ingentaconnect.com
The perilous increase of Pseudomonas aeruginosa resistance and its great ability to
produce several virulence factors is an emergent global health problem. Further …

Inhibition of biofilm formation, quorum sensing and virulence factor production in Pseudomonas aeruginosa PAO1 by selected LasR inhibitors

A Vetrivel, P Vetrivel, K Dhandapani… - International …, 2023 - Springer
The quorum sensing network of Pseudomonas aeruginosa mediates the regulation of genes
controlling biofilm formation and virulence factors. The rise of drug resistance to …

In silico identification of lead compounds for Pseudomonas aeruginosa PqsA enzyme: Computational study to block biofilm formation

M Shahab, M Danial, T Khan, C Liang, X Duan… - Biomedicines, 2023 - mdpi.com
Pseudomonas aeruginosa is an opportunistic Gram-negative bacterium implicated in acute
and chronic nosocomial infections and a leading cause of patient mortality. Pseudomonas …

Design and synthesis of novel benzimidazole derivatives as potential Pseudomonas aeruginosa anti-biofilm agents inhibiting LasR: Evidence from comprehensive …

RH Abd El-Aleam, AM Sayed, MN Taha… - European Journal of …, 2022 - Elsevier
Quorum sensing (QS) inhibition is one of the potential methods to target bacterial infection.
In this study, comprehensive molecular dynamics simulation (MDS) experiments were …