Highlights•Modern neurotrophin delivery systems should be able to cure neuronal
loss.•Gene carriers deliver stable neurotrophic proteins to specific brain regions.•Delivery …

Neurodegenerative diseases represent a major public health problem, but beneficial clinical
treatment with neurotrophic factors has not been established yet. The therapeutic use of …

The central nervous system (CNS) plays a central role in the control of sensory and motor
functions, and the disruption of its barriers can result in severe and debilitating neurological …

Brain research is the most expanding interdisciplinary research that is using the state of the
art techniques to overcome limitations in order to conduct more accurate and effective …

This review highlights recent work on the use of biomaterial-based drug delivery systems to
control the release of neurotrophic factors as a potential strategy for the treatment of …

Nanoparticulate delivery systems represent an area of particular promise for
nanoneuromedicines. They possess significant potential for desperately needed therapies …

Introduction Neurodegenerative diseases are those wherein the neurons in the brain or
peripheral nervous system lose their function, eventually culminating in neuronal death …

Nanomedicine has focused on targeted neurotrophic gene delivery to the brain as a strategy
to stop and reverse neurodegeneration in Parkinson's disease. Because of improved …

Among the macromolecular drug targets in neurodegenerative disorders, the neurotrophin
brain-derived neurotrophic factor (BDNF) and its high-affinity tropomyosin-related kinase …

Neurotrophic factors (NTFs) are small secreted proteins that support the development,
maturation and survival of neurons. NTFs injected into the brain rescue and regenerate …