Beyond shielding: the roles of glycans in the SARS-CoV-2 spike protein

L Casalino, Z Gaieb, JA Goldsmith, CK Hjorth… - ACS central …, 2020 - ACS Publications
The ongoing COVID-19 pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has resulted in more than 28,000,000 infections and 900,000 …

Structure, dynamics, receptor binding, and antibody binding of the fully glycosylated full-length SARS-CoV-2 spike protein in a viral membrane

YK Choi, Y Cao, M Frank, H Woo, SJ Park… - Journal of Chemical …, 2021 - ACS Publications
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
mediates host cell entry by binding to angiotensin-converting enzyme 2 (ACE2) and is …

The answer lies in the energy: how simple atomistic molecular dynamics simulations may hold the key to epitope prediction on the fully glycosylated SARS-CoV-2 …

SA Serapian, F Marchetti, A Triveri… - The Journal of …, 2020 - ACS Publications
SARS-CoV-2 is a health threat with dire socioeconomical consequences. As the crucial
mediator of infection, the viral glycosylated spike protein (S) has attracted the most attention …

[HTML][HTML] SARS-CoV-2 spike opening dynamics and energetics reveal the individual roles of glycans and their collective impact

YT Pang, A Acharya, DL Lynch, A Pavlova… - Communications …, 2022 - nature.com
The trimeric spike (S) glycoprotein, which protrudes from the SARS-CoV-2 viral envelope,
binds to human ACE2, initiated by at least one protomer's receptor binding domain (RBD) …

[HTML][HTML] Analysis of the SARS-CoV-2 spike protein glycan shield reveals implications for immune recognition

OC Grant, D Montgomery, K Ito, RJ Woods - Scientific reports, 2020 - nature.com
Here we have generated 3D structures of glycoforms of the spike (S) glycoprotein from
SARS-CoV-2, based on reported 3D structures and glycomics data for the protein produced …

[HTML][HTML] A glycan gate controls opening of the SARS-CoV-2 spike protein

T Sztain, SH Ahn, AT Bogetti, L Casalino… - Nature …, 2021 - nature.com
SARS-CoV-2 infection is controlled by the opening of the spike protein receptor binding
domain (RBD), which transitions from a glycan-shielded 'down'to an exposed 'up'state to …

Developing a fully glycosylated full-length SARS-CoV-2 spike protein model in a viral membrane

H Woo, SJ Park, YK Choi, T Park… - The journal of …, 2020 - ACS Publications
This technical study describes all-atom modeling and simulation of a fully glycosylated full-
length SARS-CoV-2 spike (S) protein in a viral membrane. First, starting from PDB: 6VSB …

[PDF][PDF] Elucidation of interactions regulating conformational stability and dynamics of SARS-CoV-2 S-protein

T Mori, J Jung, C Kobayashi, HM Dokainish, S Re… - Biophysical journal, 2021 - cell.com
The ongoing COVID-19 pandemic caused by the new coronavirus, SARS-CoV-2, calls for
urgent developments of vaccines and antiviral drugs. The spike protein of SARS-CoV-2 (S …

[HTML][HTML] Glycans on the SARS-CoV-2 spike control the receptor binding domain conformation

R Henderson, RJ Edwards, K Mansouri, K Janowska… - BioRxiv, 2020 - ncbi.nlm.nih.gov
The glycan shield of the beta-coronavirus (β-CoV) Spike (S) glycoprotein provides protection
from host immune responses, acting as a steric block to potentially neutralizing antibody …

[HTML][HTML] Site-specific analysis of the SARS-CoV-2 glycan shield

Y Watanabe, JD Allen, D Wrapp, JS McLellan… - BioRxiv, 2020 - ncbi.nlm.nih.gov
The emergence of the betacoronavirus, SARS-CoV-2 that causes COVID-19, represents a
significant threat to global human health. Vaccine development is focused on the principal …